Is increased uric acid a risk factor or a defensive response? The Campania Salute Network

Circulating uric acid (UA) is positively associated with body mass index (BMI), blood glucose, blood pressure (BP), markers of inflammation, and altered lipid profile. UA has also anti-oxidative properties which might be beneficial for cardiovascular (CV) system. It is still debated whether or not U...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2018-08, Vol.28 (8), p.839-846
Main Authors: Mancusi, C., Izzo, R., Ferrara, L.A., Rozza, F., Losi, M.A., Canciello, G., Pepe, M., de Luca, N., Trimarco, B., de Simone, G.
Format: Article
Language:English
Subjects:
Arterial hypertension
Campania Salute
CV risk
Major cardiovascular events
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Circulating uric acid (UA) is positively associated with body mass index (BMI), blood glucose, blood pressure (BP), markers of inflammation, and altered lipid profile. UA has also anti-oxidative properties which might be beneficial for cardiovascular (CV) system. It is still debated whether or not UA is independently associated with increased CV morbidity and/or mortality. We studied prognostic impact of UA in 8833 hypertensive adults (mean age 53 ± 12 yrs, 3857 women) from the Campania Salute Network, without prevalent CV disease and more than stage 3 CKD. We calculated standardized UA Z-score, adjusted for age, sex, glomerular filtration rate, and BMI. Low and high UA and UA Z-score quartiles were compared to the 2 middle quartiles assumed to be “normal”. Prevalence of obesity and diabetes was higher in low and high than in normal UA Z-score group (all p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2018.04.013