Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure

To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis. Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis. Plasma mi...

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Bibliographic Details
Published in:Biomarkers in medicine 2018-08, Vol.12 (8), p.871-880
Main Authors: Li, Gang, Song, Ying, Li, Yun-Da, Jie, Ling-Jun, Wu, Wei-Yin, Li, Jing-Zhou, Zhang, Qiuwang, Wang, Yan
Format: Article
Language:English
Subjects:
Biomarkers
Cardiology
Cardiomyocytes
Cardiovascular disease
circulating miRNAs
Collaboration
Congestive heart failure
Diagnosis
Enzymes
Gene expression
Heart attacks
Heart failure
Hypoxia
Laboratories
Medical diagnosis
MicroRNAs
miR-302 cluster
miRNA
receiver operating characteristic curve analysis
RT-qPCR
Stem cells
Ventricle
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Summary:To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis. Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis. Plasma miR-302s except miR-302f were significantly elevated in AHF patients. MiR-302b-3p had the highest area under curve value of 0.87. There were strong positive correlations between miR-302s and NT-proBNP levels. MiR-302b-3p levels were significantly higher in left ventricular ejection fraction ≤45% and New York Heart Association class IV patients compared with left ventricular ejection fraction >45% and New York Heart Association class II patients, respectively. Levels of circulating miR-302s, miR-302b-3p in particular, could be potentially applied for AHF diagnosis and the differentiation of disease severity.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2018-0132