Mycobacterial Lipids Induce Calcium Mobilization and Degranulation of Mast Cells

When a susceptible host is exposed to Mycobacterium tuberculosis, the bacteria translocate to the mucosal barrier, interacting with a variety of immune cells, including mast cells (MCs). MCs are abundant in the lung tissue, where they act as sentinels for a wide variety of invading pathogens, as wel...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2018-09, Vol.198 (6), p.813-816
Main Authors: Torres-Atencio, Ivonne, Rosero, Sara, Ordoñez, Ciara, Ruiz, Michelle, Goodridge, Amador
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Castro, Irene
Cell Line
Infections
Lipids
Lipids - pharmacology
Mast Cells - drug effects
Mast Cells - metabolism
Mast Cells - pathology
Mice
Mycobacterium tuberculosis
Rodents
Tuberculosis
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Summary:When a susceptible host is exposed to Mycobacterium tuberculosis, the bacteria translocate to the mucosal barrier, interacting with a variety of immune cells, including mast cells (MCs). MCs are abundant in the lung tissue, where they act as sentinels for a wide variety of invading pathogens, as well as regulatory cells during the course of acute inflammation (4). Besides specific antigen-driven IgE crosslink stimulation, MCs can be activated by complement components, IgG, neuropeptides, pathogen-associated molecular patterns, mainly peptides, and whole M. tuberculosis interaction (5). Stem-cell factor, the kit ligand, induces direct degranulation of rat peritoneal mast cells in vitro and in vivo: dependence of the in vitro effect on period of culture and comparisons of stem-cell factor with other mast cell-activating agents.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201803-0436LE