Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis

The amount of fluoride present naturally in drinking water is highly variable, being dependent upon the individual geological environment from which the water is obtained. Chronic exposure to exceeding fluoride doses induces set of toxic effects, i.e. fluorosis. The aim of this study was to examine...

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Bibliographic Details
Published in:Food and chemical toxicology 2009-06, Vol.47 (6), p.1080-1084
Main Authors: Mandinic, Zoran, Curcic, Marijana, Antonijevic, Biljana, Lekic, Charles P., Carevic, Momir
Format: Article
Language:English
Subjects:
Algorithms
Bean
beans
Biological and medical sciences
Child
children
dental caries
Dental fluorosis
dietary nutrient sources
Environmental Exposure
Fabaceae - chemistry
Female
Fluoride intake
fluorides
Fluorides - adverse effects
Fluorides - analysis
fluorosis
Fluorosis, Dental - epidemiology
Food Analysis
Humans
Logistic Models
Male
Medical sciences
nutrient intake
Potato
potatoes
Schoolchildren
Serbia - epidemiology
Solanum tuberosum
Solanum tuberosum - chemistry
tap water
teeth
Toxicology
Water
Water Supply - analysis
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Summary:The amount of fluoride present naturally in drinking water is highly variable, being dependent upon the individual geological environment from which the water is obtained. Chronic exposure to exceeding fluoride doses induces set of toxic effects, i.e. fluorosis. The aim of this study was to examine fluoride content in water and in the most frequently used vegetables, potato and bean, grown in two different Serbian regions, i.e. control region (Valjevo) and high naturally occurring fluoride region (Vranjska Banja), and moreover, to correlate estimated daily intake with dental fluorosis occurrence as an adverse effect of fluoride exposure of schoolchildren in Serbia. Study confirmed significant difference in fluoride content in water, potato and bean, consumed by 12-year-old children in two investigated municipalities. Results of the study indicated positive and statistically significant correlation between daily intake of fluoride and dental fluorosis level in the fluorotic municipality of Vranjska Banja (r=0.61; p=0.000017). Obtained relationship could be evaluated by means of binary logistic regression analysis, whereas probability for fluorosis occurrence could be predicted using the following equation: fluorosis occurence (%)=(34.852×Cwater−12.644×Cpotato−9.362×Cbean−7.673)×100 (Chi-Square (3)=33.033; p
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2009.01.038