The distribution of intratumoral macrophages correlates with molecular phenotypes and impacts prognosis in colorectal carcinoma

Aims The role of tumour‐associated macrophages (TAMs) in colorectal cancer (CRC) remains elusive. In this study, we aimed to examine the correlation between TAMs, clinicopathological features, tumour‐infiltrating lymphocytes (TILs) and prognosis in CRC by the use of image analysis. Methods and resul...

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Bibliographic Details
Published in:Histopathology 2018-10, Vol.73 (4), p.663-671
Main Authors: Kim, Younghoon, Wen, Xianyu, Bae, Jeong M, Kim, Jung H, Cho, Nam‐Yun, Kang, Gyeong H
Format: Article
Language:English
Subjects:
Adult
Aged
CD163 antigen
CD3 antigen
CD8 antigen
Colorectal carcinoma
Colorectal Neoplasms - immunology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
computer‐assisted image analysis
CpG islands
Female
Humans
Image processing
Kaplan-Meier Estimate
Lymphocytes T
Lymphocytes, Tumor-Infiltrating - immunology
Macrophages
Macrophages - immunology
Male
Medical prognosis
Microsatellite instability
Middle Aged
Phenotype
Phenotypes
Prognosis
Progression-Free Survival
Proportional Hazards Models
Tumors
tumour‐infiltrating lymphocytes
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Summary:Aims The role of tumour‐associated macrophages (TAMs) in colorectal cancer (CRC) remains elusive. In this study, we aimed to examine the correlation between TAMs, clinicopathological features, tumour‐infiltrating lymphocytes (TILs) and prognosis in CRC by the use of image analysis. Methods and results Immunohistochemical staining for CD68 and CD163 was performed as pan‐macrophage and M2‐macrophage markers, respectively. Each marker was analysed separately for intra‐epithelial and stromal area densities. All four macrophage densities showed a significant correlation with one another (P = 0.001). Intra‐epithelial CD68+ macrophage densities showed a correlation with pTNM stage (P = 0.008), microsatellite instability (MSI) (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.13674