CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid

Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset r...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 2018-08, Vol.164 (2), p.77-85
Main Authors: Asano, Kenichi, Kikuchi, Kenta, Tanaka, Masato
Format: Article
Language:English
Subjects:
Animals
Humans
Intestines - immunology
Macrophages - immunology
Neoplastic Cells, Circulating - immunology
Sialic Acid Binding Ig-like Lectin 1 - immunology
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Summary:Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169+ macrophages in the lymphoid organs capture blood- and lymph-borne particulate materials. Antigen information relayed by CD169+ macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169+ macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169+ macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.
ISSN:0021-924X
1756-2651
DOI:10.1093/jb/mvy050