CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid

Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset r...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 2018-08, Vol.164 (2), p.77-85
Main Authors: Asano, Kenichi, Kikuchi, Kenta, Tanaka, Masato
Format: Article
Language:English
Subjects:
Animals
Humans
Intestines - immunology
Macrophages - immunology
Neoplastic Cells, Circulating - immunology
Sialic Acid Binding Ig-like Lectin 1 - immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 85
container_issue 2
container_start_page 77
container_title Journal of biochemistry (Tokyo)
container_volume 164
creator Asano, Kenichi
Kikuchi, Kenta
Tanaka, Masato
description Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169+ macrophages in the lymphoid organs capture blood- and lymph-borne particulate materials. Antigen information relayed by CD169+ macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169+ macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169+ macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.
doi_str_mv 10.1093/jb/mvy050
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2056390072</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jb/mvy050</oup_id><sourcerecordid>2056390072</sourcerecordid><originalsourceid>FETCH-LOGICAL-o170t-f395a4df089c08cf062e56f0a0da59107d330789632493fc89ace83c33243c4c3</originalsourceid><addsrcrecordid>eNo9kD1PwzAURS0EoqUw8AeQBwaW0Gc7TuIRlU-pEgtIbJHrOK2rOA52Auq_xyWF5V1dnaM3XIQuCdwSEGy-Xc3t1w44HKEpyXmW0IyTYzQFoCQRNP2YoLMQtvtKGTtFEyoE8IKTKZKLe5IJbKXyrtvItQ7Y6_XQyF5jY-3Q6thD59oQSe--pa9wJ31v1OjYeLyRTcCmxf1GY2X8LzLtGtfNYKpzdFJHri8OOUPvjw9vi-dk-fr0srhbJo7k0Cc1E1ymVQ2FUFCoGjKqeVaDhEpyQSCvGIO8EBmjqWC1KoRUumCKxc5UqtgM3Yx_O-8-Bx360pqgdNPIVrshlBR4xgRATqN6dVCHldVV2Xljpd-Vf7NE4XoU3ND9UwLlfu1yuyrHtdkPKYNwjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2056390072</pqid></control><display><type>article</type><title>CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid</title><source>Oxford Journals Online</source><creator>Asano, Kenichi ; Kikuchi, Kenta ; Tanaka, Masato</creator><creatorcontrib>Asano, Kenichi ; Kikuchi, Kenta ; Tanaka, Masato</creatorcontrib><description>Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169+ macrophages in the lymphoid organs capture blood- and lymph-borne particulate materials. Antigen information relayed by CD169+ macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169+ macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169+ macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.</description><identifier>ISSN: 0021-924X</identifier><identifier>EISSN: 1756-2651</identifier><identifier>DOI: 10.1093/jb/mvy050</identifier><identifier>PMID: 29905851</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Humans ; Intestines - immunology ; Macrophages - immunology ; Neoplastic Cells, Circulating - immunology ; Sialic Acid Binding Ig-like Lectin 1 - immunology</subject><ispartof>Journal of biochemistry (Tokyo), 2018-08, Vol.164 (2), p.77-85</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29905851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asano, Kenichi</creatorcontrib><creatorcontrib>Kikuchi, Kenta</creatorcontrib><creatorcontrib>Tanaka, Masato</creatorcontrib><title>CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid</title><title>Journal of biochemistry (Tokyo)</title><addtitle>J Biochem</addtitle><description>Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169+ macrophages in the lymphoid organs capture blood- and lymph-borne particulate materials. Antigen information relayed by CD169+ macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169+ macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169+ macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.</description><subject>Animals</subject><subject>Humans</subject><subject>Intestines - immunology</subject><subject>Macrophages - immunology</subject><subject>Neoplastic Cells, Circulating - immunology</subject><subject>Sialic Acid Binding Ig-like Lectin 1 - immunology</subject><issn>0021-924X</issn><issn>1756-2651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNo9kD1PwzAURS0EoqUw8AeQBwaW0Gc7TuIRlU-pEgtIbJHrOK2rOA52Auq_xyWF5V1dnaM3XIQuCdwSEGy-Xc3t1w44HKEpyXmW0IyTYzQFoCQRNP2YoLMQtvtKGTtFEyoE8IKTKZKLe5IJbKXyrtvItQ7Y6_XQyF5jY-3Q6thD59oQSe--pa9wJ31v1OjYeLyRTcCmxf1GY2X8LzLtGtfNYKpzdFJHri8OOUPvjw9vi-dk-fr0srhbJo7k0Cc1E1ymVQ2FUFCoGjKqeVaDhEpyQSCvGIO8EBmjqWC1KoRUumCKxc5UqtgM3Yx_O-8-Bx360pqgdNPIVrshlBR4xgRATqN6dVCHldVV2Xljpd-Vf7NE4XoU3ND9UwLlfu1yuyrHtdkPKYNwjw</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Asano, Kenichi</creator><creator>Kikuchi, Kenta</creator><creator>Tanaka, Masato</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20180801</creationdate><title>CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid</title><author>Asano, Kenichi ; Kikuchi, Kenta ; Tanaka, Masato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o170t-f395a4df089c08cf062e56f0a0da59107d330789632493fc89ace83c33243c4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Intestines - immunology</topic><topic>Macrophages - immunology</topic><topic>Neoplastic Cells, Circulating - immunology</topic><topic>Sialic Acid Binding Ig-like Lectin 1 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asano, Kenichi</creatorcontrib><creatorcontrib>Kikuchi, Kenta</creatorcontrib><creatorcontrib>Tanaka, Masato</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asano, Kenichi</au><au>Kikuchi, Kenta</au><au>Tanaka, Masato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid</atitle><jtitle>Journal of biochemistry (Tokyo)</jtitle><addtitle>J Biochem</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>164</volume><issue>2</issue><spage>77</spage><epage>85</epage><pages>77-85</pages><issn>0021-924X</issn><eissn>1756-2651</eissn><abstract>Abstract Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169+ macrophages in the lymphoid organs capture blood- and lymph-borne particulate materials. Antigen information relayed by CD169+ macrophages to neighbouring immune cells is important for enhancement of antimicrobial and antitumour immunity as well as induction of tolerance. In the intestinal tract, CD169+ macrophages localize distantly from epithelial border. Following mucosal injury, they exacerbate inflammation by producing CCL8 that recruits inflammatory monocytes. As such, a better understanding of CD169+ macrophage phenotypes may enable the design of tissue-specific therapies for both immunological and non-immunological diseases.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29905851</pmid><doi>10.1093/jb/mvy050</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0021-924X
ispartof Journal of biochemistry (Tokyo), 2018-08, Vol.164 (2), p.77-85
issn 0021-924X
1756-2651
language eng
recordid cdi_proquest_miscellaneous_2056390072
source Oxford Journals Online
subjects Animals
Humans
Intestines - immunology
Macrophages - immunology
Neoplastic Cells, Circulating - immunology
Sialic Acid Binding Ig-like Lectin 1 - immunology
title CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T13%3A53%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD169%20macrophages%20regulate%20immune%20responses%20toward%20particulate%20materials%20in%20the%20circulating%20fluid&rft.jtitle=Journal%20of%20biochemistry%20(Tokyo)&rft.au=Asano,%20Kenichi&rft.date=2018-08-01&rft.volume=164&rft.issue=2&rft.spage=77&rft.epage=85&rft.pages=77-85&rft.issn=0021-924X&rft.eissn=1756-2651&rft_id=info:doi/10.1093/jb/mvy050&rft_dat=%3Cproquest_pubme%3E2056390072%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-o170t-f395a4df089c08cf062e56f0a0da59107d330789632493fc89ace83c33243c4c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2056390072&rft_id=info:pmid/29905851&rft_oup_id=10.1093/jb/mvy050&rfr_iscdi=true