Surgical versus non‐surgical treatment of actinic cheilitis: A systematic review and meta‐analysis

Objective The aim of this systematic review was to compare outcomes between surgical and non‐surgical treatment of actinic cheilitis (AC). Materials and Methods A systematic review and meta‐analysis based on the Preferred Reporting Items for Systematic reviews and Meta‐Analyses guideline were perfor...

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Bibliographic Details
Published in:Oral diseases 2019-05, Vol.25 (4), p.972-981
Main Authors: Carvalho, Marianne de Vasconcelos, Moraes, Sandra Lúcia Dantas, Lemos, Cleidiel Aparecido Araujo, Santiago Júnior, Joel Ferreira, Vasconcelos, Belmiro Cavalcanti do Egito, Pellizzer, Eduardo Piza
Format: Article
Language:English
Subjects:
actinic cheilitis
Biopsy
Cheilitis - pathology
Cheilitis - therapy
Clinical trials
Data processing
Dentistry
Humans
intervention
management
Meta-analysis
Neoplasm Recurrence, Local
Prospective Studies
Remission
Retrospective Studies
Standardization
Systematic review
Treatment Outcome
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Summary:Objective The aim of this systematic review was to compare outcomes between surgical and non‐surgical treatment of actinic cheilitis (AC). Materials and Methods A systematic review and meta‐analysis based on the Preferred Reporting Items for Systematic reviews and Meta‐Analyses guideline were performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective/retrospective studies, and case series with at least 10 patients, with a minimum follow‐up period of 6 months. A weighted remission rate (RER) and recurrence rate (RR) with a 95% confidence interval was performed. Data analysis was performed using a comprehensive meta‐analysis software. Results A total of 283 ACs in 10 studies were included. About 2.5% surgically treated cases underwent malignant transformation. The weighted remission rate was higher for surgical (92.8%) compared to non‐surgical treatment (65.9%). The recurrence rate was lower for surgical (8.4%) compared to non‐surgical treatment (19.2%). Conclusion In this systematic review, the surgical treatment was more favorable than non‐surgical for AC. Meanwhile, further studies are needed that should maximize methodological standardization and have greater rigor of the data collection process.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12916