Emergence of diversity in homogeneous coupled Boolean networks

The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a v...

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Bibliographic Details
Published in:Physical review. E 2018-05, Vol.97 (5-1), p.052415-052415, Article 052415
Main Authors: Kang, Chris, Aguilar, Boris, Shmulevich, Ilya
Format: Article
Language:English
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Summary:The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.
ISSN:2470-0045
2470-0053
DOI:10.1103/PhysRevE.97.052415