Emergence of diversity in homogeneous coupled Boolean networks

The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a v...

Full description

Saved in:
Bibliographic Details
Published in:Physical review. E 2018-05, Vol.97 (5-1), p.052415-052415, Article 052415
Main Authors: Kang, Chris, Aguilar, Boris, Shmulevich, Ilya
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43
cites cdi_FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43
container_end_page 052415
container_issue 5-1
container_start_page 052415
container_title Physical review. E
container_volume 97
creator Kang, Chris
Aguilar, Boris
Shmulevich, Ilya
description The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.
doi_str_mv 10.1103/PhysRevE.97.052415
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2056395516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2056395516</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43</originalsourceid><addsrcrecordid>eNo9kEtPwzAQhC0EolXpH-CAcuSSsrbjpL4gQVUeUiUQgrNlOxsaSOJiJ6367wn0cdqRdmY0-gi5pDChFPjN63Ib3nA9n8hsAoIlVJyQIUsyiAEEPz3qRAzIOIQvAKApyIyyczJgUkIqaTIkt_Ma_Sc2FiNXRHm5Rh_KdhuVTbR0tes_6LoQWdetKsyje-cq1E3UYLtx_jtckLNCVwHH-zsiHw_z99lTvHh5fJ7dLWLLgbdxXuR5YYQ1yDSTQpqE26kxYKROEzsFmWpbIDP9qpQWVlIpBKOGccPzTGPCR-R617vy7qfD0Kq6DBarSv_vUwxEyvsQTXsr21mtdyF4LNTKl7X2W0VB_aFTB3RKZmqHrg9d7fs7U2N-jBxA8V_hQ2wr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2056395516</pqid></control><display><type>article</type><title>Emergence of diversity in homogeneous coupled Boolean networks</title><source>American Physical Society:Jisc Collections:APS Read and Publish 2023-2025 (reading list)</source><creator>Kang, Chris ; Aguilar, Boris ; Shmulevich, Ilya</creator><creatorcontrib>Kang, Chris ; Aguilar, Boris ; Shmulevich, Ilya</creatorcontrib><description>The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.</description><identifier>ISSN: 2470-0045</identifier><identifier>EISSN: 2470-0053</identifier><identifier>DOI: 10.1103/PhysRevE.97.052415</identifier><identifier>PMID: 29906914</identifier><language>eng</language><publisher>United States</publisher><ispartof>Physical review. E, 2018-05, Vol.97 (5-1), p.052415-052415, Article 052415</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43</citedby><cites>FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29906914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Chris</creatorcontrib><creatorcontrib>Aguilar, Boris</creatorcontrib><creatorcontrib>Shmulevich, Ilya</creatorcontrib><title>Emergence of diversity in homogeneous coupled Boolean networks</title><title>Physical review. E</title><addtitle>Phys Rev E</addtitle><description>The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.</description><issn>2470-0045</issn><issn>2470-0053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPwzAQhC0EolXpH-CAcuSSsrbjpL4gQVUeUiUQgrNlOxsaSOJiJ6367wn0cdqRdmY0-gi5pDChFPjN63Ib3nA9n8hsAoIlVJyQIUsyiAEEPz3qRAzIOIQvAKApyIyyczJgUkIqaTIkt_Ma_Sc2FiNXRHm5Rh_KdhuVTbR0tes_6LoQWdetKsyje-cq1E3UYLtx_jtckLNCVwHH-zsiHw_z99lTvHh5fJ7dLWLLgbdxXuR5YYQ1yDSTQpqE26kxYKROEzsFmWpbIDP9qpQWVlIpBKOGccPzTGPCR-R617vy7qfD0Kq6DBarSv_vUwxEyvsQTXsr21mtdyF4LNTKl7X2W0VB_aFTB3RKZmqHrg9d7fs7U2N-jBxA8V_hQ2wr</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Kang, Chris</creator><creator>Aguilar, Boris</creator><creator>Shmulevich, Ilya</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Emergence of diversity in homogeneous coupled Boolean networks</title><author>Kang, Chris ; Aguilar, Boris ; Shmulevich, Ilya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Chris</creatorcontrib><creatorcontrib>Aguilar, Boris</creatorcontrib><creatorcontrib>Shmulevich, Ilya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physical review. E</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Chris</au><au>Aguilar, Boris</au><au>Shmulevich, Ilya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emergence of diversity in homogeneous coupled Boolean networks</atitle><jtitle>Physical review. E</jtitle><addtitle>Phys Rev E</addtitle><date>2018-05</date><risdate>2018</risdate><volume>97</volume><issue>5-1</issue><spage>052415</spage><epage>052415</epage><pages>052415-052415</pages><artnum>052415</artnum><issn>2470-0045</issn><eissn>2470-0053</eissn><abstract>The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.</abstract><cop>United States</cop><pmid>29906914</pmid><doi>10.1103/PhysRevE.97.052415</doi><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 2470-0045
ispartof Physical review. E, 2018-05, Vol.97 (5-1), p.052415-052415, Article 052415
issn 2470-0045
2470-0053
language eng
recordid cdi_proquest_miscellaneous_2056395516
source American Physical Society:Jisc Collections:APS Read and Publish 2023-2025 (reading list)
title Emergence of diversity in homogeneous coupled Boolean networks
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A26%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Emergence%20of%20diversity%20in%20homogeneous%20coupled%20Boolean%20networks&rft.jtitle=Physical%20review.%20E&rft.au=Kang,%20Chris&rft.date=2018-05&rft.volume=97&rft.issue=5-1&rft.spage=052415&rft.epage=052415&rft.pages=052415-052415&rft.artnum=052415&rft.issn=2470-0045&rft.eissn=2470-0053&rft_id=info:doi/10.1103/PhysRevE.97.052415&rft_dat=%3Cproquest_cross%3E2056395516%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c303t-dfddfb5cbe2a2959b43c8bb0b9a64c8096acfe2b90661fc9195521b23b3d7ae43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2056395516&rft_id=info:pmid/29906914&rfr_iscdi=true