Naringenin attenuates behavioral derangements induced by social defeat stress in mice via inhibition of acetylcholinesterase activity, oxidative stress and release of pro-inflammatory cytokines

The effects of naringenin; a dietary flavonoid, with potent anti-oxidant and anti-inflammatory activities on social defeat stress (SDS)-induced neurobehavioral and biochemical changes were evaluated in mice using resident-intruder paradigm. The intruder male mice were distributed into 6 groups (n = ...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2018-09, Vol.105, p.714-723
Main Authors: Umukoro, Solomon, Kalejaye, Hassanat Adeola, Ben-Azu, Benneth, Ajayi, Abayomi M.
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Animals
Behavior, Animal - drug effects
Brain - drug effects
Brain - enzymology
Brain - immunology
Cholinesterase Inhibitors - pharmacology
Cytokines - secretion
Flavanones - pharmacology
Inflammation
Male
Motor Activity - drug effects
Naringenin
Neurobehavioral deficits
Oxidative stress
Oxidative Stress - drug effects
Proinflammatory cytokines
Social defeat stress
Social Isolation - psychology
Stress, Psychological - enzymology
Stress, Psychological - immunology
Stress, Psychological - psychology
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Summary:The effects of naringenin; a dietary flavonoid, with potent anti-oxidant and anti-inflammatory activities on social defeat stress (SDS)-induced neurobehavioral and biochemical changes were evaluated in mice using resident-intruder paradigm. The intruder male mice were distributed into 6 groups (n = 6). Mice in group 1 (control) received vehicle (3% DMSO, i.p), group 2 (SDS-control) were also given vehicle, groups 3–5 received naringenin (10, 25 and 50 mg/kg, i.p.) while group 6 had ginseng (50 mg/kg, i.p) daily for 14 days. However, 30 min after treatment on day 7, mice in groups 2–6 were exposed to SDS for a period of 10 min confrontation with aggressive counterparts for 7 consecutive days. Neurobehavioral phenotypes: spontaneous motor activity (SMA), memory, anxiety and depression were then evaluated on day 14. Malondialdehyde (MDA), glutathione (GSH), catalase and superoxide dismutase (SOD) were then estimated in the brain tissues. Acetylcholinesterase (AChE) activity and the concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) were also determined. SDS-induced neurobehavioral deficits were significantly (p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2018.06.016