Pharmacokinetics of a Single Dose of Oral and Intramuscular Meloxicam in African Penguins (Spheniscus demersus)

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that has been used orally and intramuscularly in numerous avian species, but not studied to date, in African penguins (Spheniscus demersus). The study describes the pharmacokinetic parameters of meloxicam after oral and intramuscular adminis...

Full description

Saved in:
Bibliographic Details
Published in:Journal of avian medicine and surgery 2018-06, Vol.32 (2), p.102-108
Main Authors: Morrison, Jennilee, Greenacre, Cheryl B, George, Robert, Cox, Sherry, Martín-Jiménez, Tomás
Format: Article
Language:English
Subjects:
African penguin
analgesia
avian
Blood tests
Dosage and administration
Health aspects
Meloxicam
nonsteroidal anti-inflammatory
ORIGINAL STUDIES
Original Study
pharmacokinetic
Pharmacokinetics
Spheniscus demersus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that has been used orally and intramuscularly in numerous avian species, but not studied to date, in African penguins (Spheniscus demersus). The study describes the pharmacokinetic parameters of meloxicam after oral and intramuscular administration to African penguins. Several pilot studies were conducted initially where meloxicam (1, 0.5, and 0.25 mg/kg) was given intramuscularly to 4 birds, and orally (1 mg/kg) to 2 birds. Based on pilot study results, one group of 8 penguins was given meloxicam 0.5 mg/kg intramuscularly and one group of 8 penguins was given 1 mg/kg orally. Blood samples were collected at baseline and at 11 time intervals per group after administration of meloxicam. Meloxicam time to maximum plasma concentration (Tmax), maximum concentration (Cmax), and half-life (t1/2) after intramuscular administration were 1.00 hour, 8.03 μg/mL, and 31.87 hours, respectively, while oral administration produced a Tmax, Cmax, and t1/2 of 12.00 hours, 10.84 μg/mL, and 28.59 hours, respectively. Based on plasma meloxicam concentrations found to be therapeutic in other bird species and humans, the recommended dosage and frequency for African penguins is 1 mg/kg orally every 48 hours and 0.5 mg/kg intramuscularly every 24 hours. Further studies are needed to determine the multiple-dose pharmacokinetics of meloxicam in African penguins.
ISSN:1082-6742
1938-2871
DOI:10.1647/2017-281