Effects of increasing doses of samarium-153-ethylenediaminetetramethylene phosphonate on axial and appendicular skeletal growth in juvenile rabbits

Abstract Introduction Targeted radiotherapy using samarium-153-ethylenediaminetetramethylene phosphonate (153 Sm-EDTMP) is currently under investigation for treatment of osteosarcoma. Osteosarcoma often occurs in children, and previous studies on a juvenile rabbit model demonstrated that clinically...

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Bibliographic Details
Published in:Nuclear medicine and biology 2008-02, Vol.35 (2), p.219-225
Main Authors: Essman, Stephanie C, Lewis, Michael R, Fox, Derek B
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - diagnostic imaging
Bone and Bones - radiation effects
Bone Development - radiation effects
Bone growth
Dose-Response Relationship, Radiation
Female
Growth Plate - diagnostic imaging
Growth Plate - radiation effects
Organophosphonates - pharmacokinetics
Osteosarcoma
Physeal cartilage
Rabbits
Radioisotopes - adverse effects
Radioisotopes - pharmacokinetics
Radiology
Radionuclide Imaging
Radiopharmaceuticals - adverse effects
Radiopharmaceuticals - pharmacokinetics
Radiotherapy Dosage
Samarium - pharmacokinetics
Samarium-153-ethylenediaminetetramethylene phosphonate
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Summary:Abstract Introduction Targeted radiotherapy using samarium-153-ethylenediaminetetramethylene phosphonate (153 Sm-EDTMP) is currently under investigation for treatment of osteosarcoma. Osteosarcoma often occurs in children, and previous studies on a juvenile rabbit model demonstrated that clinically significant damage to developing physeal cartilage may occur as a result of systemic153 Sm-EDTMP therapy. The aim of this study was to evaluate the late effects of153 Sm-EDTMP on skeletal structures during growth to maturity and to determine if there is a dose response of153 Sm-EDTMP on growth of long bones. Methods Female 8-week-old New Zealand white rabbits were divided into three treatment groups plus controls. Each rabbit was intravenously administered a predetermined dose of153 Sm-EDTMP. Multiple bones of each rabbit were radiographed every 2 months until physeal closure, with subsequent measurements made to assess for abbreviated bone growth. Statistical analyses were performed to determine the differences in bone length between groups, with significance set at P
ISSN:0969-8051
1872-9614
DOI:10.1016/j.nucmedbio.2007.11.005