“It Was Not My Aim to Sleep There”: The Impact of Timing and Location of Sex on Adherence to Coitally-Dependent HIV Pre-exposure Prophylaxis

The FACTS 001 trial found that vaginal pre- and post-coital application of 1% tenofovir gel did not prevent HIV-1 infection amongst young South African women. The trial included a multi-faceted approach to adherence support and collected objective and self-reported adherence measures. Using qualitat...

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Published in:AIDS and behavior 2018-11, Vol.22 (11), p.3692-3704
Main Authors: Scorgie, Fiona, Stadler, Jonathan, Baron, Deborah, Ju, Susan, Ikaneng, Tshepiso, Mabude, Zonke, Makgopa, Sylvia, Malefo, Matshidiso A., Manenzhe, Kgahlisho N., Mazibuko, Thulani, Ntjana, Hilda, Nkala, Busi, Palanee-Phillips, Thesla, Gray, Glenda, Rees, Helen, Delany-Moretlwe, Sinead
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adhesion
AIDS
Antiretroviral drugs
Autonomy
Disease prevention
Females
Health Psychology
HIV
Human immunodeficiency virus
Infectious Diseases
Intimacy
Medicine
Medicine & Public Health
Original Paper
Parents
Parents & parenting
Privacy
Prophylaxis
Public Health
Qualitative analysis
Sex
Sexually transmitted diseases
Sleep
STD
Tenofovir
Vagina
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cited_by cdi_FETCH-LOGICAL-c372t-656a4c425b0accbc6007bc6f3fe47f529618a2fe153a92a4f14347c7bf53ce483
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creator Scorgie, Fiona
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Baron, Deborah
Ju, Susan
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Manenzhe, Kgahlisho N.
Mazibuko, Thulani
Ntjana, Hilda
Nkala, Busi
Palanee-Phillips, Thesla
Gray, Glenda
Rees, Helen
Delany-Moretlwe, Sinead
description The FACTS 001 trial found that vaginal pre- and post-coital application of 1% tenofovir gel did not prevent HIV-1 infection amongst young South African women. The trial included a multi-faceted approach to adherence support and collected objective and self-reported adherence measures. Using qualitative data collected from a random sub-set of FACTS 001 participants (135 in-depth interviews at product discontinuation and 13 focus group discussions at dissemination of trial results), we explore the importance of ‘place’ and ‘timing’ in shaping acts of sexual intimacy and product adherence. Demographically, this qualitative sub-sample is similar to the trial cohort of predominantly young, unemployed women living with parents or other family members. Sexual intimacy was largely unpredictable and happened across multiple locations in which women had limited privacy, autonomy, or control over the timing of sex. This made adherence to the dosing strategy challenging. Findings may inform the development of future event-driven pre-exposure prophylaxis regimens or products.
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subjects Acquired immune deficiency syndrome
Adhesion
AIDS
Antiretroviral drugs
Autonomy
Disease prevention
Females
Health Psychology
HIV
Human immunodeficiency virus
Infectious Diseases
Intimacy
Medicine
Medicine & Public Health
Original Paper
Parents
Parents & parenting
Privacy
Prophylaxis
Public Health
Qualitative analysis
Sex
Sexually transmitted diseases
Sleep
STD
Tenofovir
Vagina
title “It Was Not My Aim to Sleep There”: The Impact of Timing and Location of Sex on Adherence to Coitally-Dependent HIV Pre-exposure Prophylaxis
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