Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?

Objective To determine the dose response effect of weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis (OA). Methods This is a secondary analysis of the diet‐induced weight loss only (D) and diet‐induced weight loss plus exercise (D + E) groups in...

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Published in:Arthritis care & research (2010) 2018-11, Vol.70 (11), p.1569-1575
Main Authors: Messier, Stephen P., Resnik, Allison E., Beavers, Daniel P., Mihalko, Shannon L., Miller, Gary D., Nicklas, Barbara J., deVita, Paul, Hunter, David J., Lyles, Mary F., Eckstein, Felix, Guermazi, Ali, Loeser, Richard F.
Format: Article
Language:English
Subjects:
Aged
Arthritis
Body Composition
Body weight
Body weight loss
Diet
Exercise
Female
Humans
Knee
Male
Middle Aged
Obesity
Obesity - complications
Obesity - diet therapy
Osteoarthritis
Osteoarthritis, Knee
Overweight
Pain
Quality of life
Weight Loss
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Summary:Objective To determine the dose response effect of weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis (OA). Methods This is a secondary analysis of the diet‐induced weight loss only (D) and diet‐induced weight loss plus exercise (D + E) groups in the Intensive Diet and Exercise for Arthritis randomized controlled clinical trial. The 240 participants were overweight and obese older community‐dwelling adults with pain and radiographic knee OA. Participants were assigned to 1 of 4 groups according to weight loss achieved over an 18‐month period:
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.23608