Biopsychosocial distress and clinical outcome in metastatic renal cell carcinoma

Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship...

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Bibliographic Details
Published in:Palliative & supportive care 2019-06, Vol.17 (3), p.353-355
Main Authors: Bergerot, Cristiane Decat, Clark, Karen Lynn, Ashing, Kimlin Tam, Bergerot, Paulo Gustavo, Obenchain, Richard, Dizman, Nazli, Hsu, JoAnn, Philip, Errol, Loscalzo, Matthew, Pal, Sumanta Kumar
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Cancer therapies
Carcinoma, Renal Cell - complications
Carcinoma, Renal Cell - psychology
Clinical outcomes
Cohort Studies
Cost estimates
Ethnicity
Female
Gender
Humans
Interactive computer systems
Kidney cancer
Laboratories
Male
Medical prognosis
Metastasis
Middle Aged
Original Article
Outcome Assessment, Health Care - methods
Outcome Assessment, Health Care - standards
Outcome Assessment, Health Care - statistics & numerical data
Patients
Psychology - trends
Secondary schools
Trends
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Summary:Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival. A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen-based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains. Association between biopsychosocial distress and clinicopathologic criteria was interrogated. Overall survival was compared between patients with low distress versus high distress.ResultHigh rates of distress (20.7%) were found among patients newly diagnosed with mRCC. Among those domains contributing to distress, pain, fatigue, and financial comorbidity were the most commonly reported by patients with mRCC. A trend toward poorer overall survival in those patients with high distress versus low distress was observed among mRCC patients.Significance of resultsBased on data from a relatively large sample of patients, this study provides the first specific insights into the potential impact of biopsychosocial distress and outcomes among patients with mRCC.
ISSN:1478-9515
1478-9523
DOI:10.1017/S1478951518000342