Neuroprotective Limonoids of Root Bark of Dictamnus dasycarpus

A methanolic extract of Dictamnus dasycarpus root bark afforded four new degraded limonoids, 9α-hydroxyfraxinellone-9-O-β-d-glucoside (1), dictamnusine (2), dictamdiol A (3), and dictamdiol B (4), together with eight known compounds, dictamdiol (5), fraxinellone (6), fraxinellonone (7), 9β-hydroxyfr...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-02, Vol.71 (2), p.208-211
Main Authors: Yoon, Jeong Seon, Sung, Sang Hyun, Kim, Young Choong
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells, Cultured
Cerebral Cortex - cytology
Cerebral Cortex - drug effects
Dictamnus - chemistry
General pharmacology
Korea
Limonins - chemistry
Limonins - isolation & purification
Limonins - pharmacology
Medical sciences
Molecular Structure
Neuroprotective Agents - chemistry
Neuroprotective Agents - isolation & purification
Neuroprotective Agents - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark - chemistry
Plant Roots - chemistry
Plants, Medicinal - chemistry
Rats
Rats, Sprague-Dawley
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Summary:A methanolic extract of Dictamnus dasycarpus root bark afforded four new degraded limonoids, 9α-hydroxyfraxinellone-9-O-β-d-glucoside (1), dictamnusine (2), dictamdiol A (3), and dictamdiol B (4), together with eight known compounds, dictamdiol (5), fraxinellone (6), fraxinellonone (7), 9β-hydroxyfraxinellone (8), calodendrolide (9), obacunone (10), limonin (11), and rutaevin (12). Compounds, 2, 3, 6, 9, 10, and 11 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 µM.
ISSN:0163-3864
1520-6025
DOI:10.1021/np070588o