Diagnostic accuracy of immunohistochemical markers in differentiation between basal cell carcinoma and trichoepithelioma in small biopsy specimens

Background The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis. Objectives To develop an immunohistochemica...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cutaneous pathology 2018-11, Vol.45 (11), p.807-816
Main Authors: Mostafa, Naglaa A., Assaf, Magda, Elhakim, Sami, Abdel‐Halim, Mona R. E., El‐Nabarawy, Eman, Gharib, Khaled
Format: Article
Language:English
Subjects:
Accuracy
Aged
Androgen receptors
Basal cell carcinoma
Biomarkers, Tumor - analysis
Biopsy
Carcinoma, Basal Cell - diagnosis
CD10
CK19
Diagnosis, Differential
Differential diagnosis
Female
Humans
Immunohistochemistry
Immunoreactivity
Ki‐67
Male
Neoplasms, Adnexal and Skin Appendage - diagnosis
PHLDA1
Skin Neoplasms - diagnosis
Statistical analysis
Trichoepithelioma
Tumor cells
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis. Objectives To develop an immunohistochemical protocol that helps in differentiation between both trichoepithelioma (TE) and basal cell carcinoma (BCC) with higher sensitivity and specificity. Methods Using standard immunohistochemical techniques, we examined 10 TEs and 19 BCCs for the expression of CK19, Ki‐67, androgen receptors (AR), CD10, and PHLDA1. Results Immunoreactivity of AR, Ki‐67, and CD10 in tumor cells was significantly higher in BCC than TE with a diagnostic accuracy in BCC of 75.5%, 75.8%, and 79.3% respectively, whereas immunoreactivity of PHLDA1 in tumor cells and stromal CD10 was significantly higher in TE than BCC with a diagnostic accuracy in TE of 100% and 82.8%, respectively. In contrast, immunoreactivity for CK19 showed no statistically significant differences between both tumors. Conclusion The analysis of CD10, Ki‐67, and PHLDA1 can be used as a helpful immunohistochemical panel in the distinction between TE and BCC especially in small and superficial biopsies.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13305