Mild, Fast, and Easy To Conduct MoCl5‑Mediated Dehydrogenative Coupling Reactions in Flow

A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, bi...

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Bibliographic Details
Published in:Organic letters 2018-07, Vol.20 (13), p.4107-4110
Main Authors: Beil, Sebastian B, Uecker, Ise, Franzmann, Peter, Müller, Timo, Waldvogel, Siegfried R
Format: Article
Language:English
Online Access:Get full text
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Summary:A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, biphenyls could be obtained in 21–91% isolated yield. This simple protocol opens a new chapter in reagent-mediated dehydrogenative coupling reactions, and yields are compared to classical approaches.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01664