Roles of Albumin‐Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery

• Published in: Chembiochem : a European journal of chemical biology 2018-09, Vol.19 (17), p.1796-1805
• Main Authors: Zhao, Pengfei, Wang, Yonghui, Wu, Aihua, Rao, Yuefeng, Huang, Yongzhuo
• Format: Article
• Language: English
• Subjects: Albumin; albumin-binding proteins; Animals; Antineoplastic Agents - therapeutic use; Binding; biomimetic delivery; Biomimetics; Biomimetics - methods; Cancer; Carrier Proteins - metabolism; Carrier Proteins - physiology; Cell Line, Tumor; Drug Carriers - metabolism; Drug delivery; Drug delivery systems; Endothelial cells; Glycoproteins - metabolism; Glycoproteins - physiology; Heterogeneous-Nuclear Ribonucleoproteins - metabolism; Heterogeneous-Nuclear Ribonucleoproteins - physiology; Humans; Metastases; Nanoparticles - therapeutic use; Neoplasms - drug therapy; Neoplasms - physiopathology; nutrient transporters; Nutrients; Osteonectin; Proteins; Receptors, Cell Surface - metabolism; Receptors, Cell Surface - physiology; Serum Albumin - metabolism; Stromal cells; Tumors
• ISSN: 1439-4227; 1439-7633
• DOI: 10.1002/cbic.201800201

Nutrient transporters have attracted significant attention for their promising application in biomimetic delivery. Due to the active consumption of nutrients, cancer cells generally overexpress nutrient transporters to meet their increased need for energy and materials. For example, albumin‐binding proteins (ABPs) are highly overexpressed in malignant cells, stromal cells, and tumor vessel endothelial cells responsible for albumin uptake. ABP (e.g., SPARC) is a promising target for tumor‐specific drug delivery, and albumin has been widely used as a biomimetic delivery carrier. Apart from the transportation function, ABPs are closely associated with neoplasia, invasion, and metastasis. Herein, a summary of the roles of ABP in cancer progression and the application of albumin‐based biomimetic tumor‐targeted delivery through the ABP pathway is presented. Special delivery: The overexpression of albumin‐binding proteins (ABPs) is closely associated with malignancy in a variety of tumors and these proteins play important roles in cancer progression. ABPs also serve as nutrient transporters for the active uptake of albumin as a major source of energy and amino acids; thus providing a promising target for tumor‐specific biomimetic drug delivery.