MHC-Linked Susceptibility to Type 1 Diabetes in the NOD Mouse

:  Although major histocompatibility complex (MHC)‐linked susceptibility is the strongest component, recent studies demonstrated that MHC‐linked susceptibility to type 1 diabetes consists of multiple components both in humans and non‐obese diabetic (NOD) mouse. In the NOD mouse, Idd16 has been mappe...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2006-10, Vol.1079 (1), p.118-121
Main Authors: FUJISAWA, TOMOMI, IKEGAMI, HIROSHI, NOSO, SHINSUKE, YAMAJI, KAORI, NOJIMA, KOJI, BABAYA, NARU, ITOI-BABAYA, MICHIKO, HIROMINE, YOSHIHISA, KOBAYASHI, MISATO, MAKINO, SUSUMU, OGIHARA, TOSHIO
Format: Article
Language:English
Subjects:
genetics
major histocompatibility complex (MHC)
NOD mouse
susceptibility gene
type 1 diabetes mellitus
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Summary::  Although major histocompatibility complex (MHC)‐linked susceptibility is the strongest component, recent studies demonstrated that MHC‐linked susceptibility to type 1 diabetes consists of multiple components both in humans and non‐obese diabetic (NOD) mouse. In the NOD mouse, Idd16 has been mapped to the region adjacent to, but distinct from Idd1 in the MHC class II region. Establishment of subcongenic NOD.CTS‐H2 lines that possess the same MHC class II as the NOD mouse but non‐NOD‐derived chromosomal region in its adjacent regions, would facilitate further narrowing down of the localization of Idd16.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1375.017