Defens-IN! Human α-Defensin 5 Acts as an Unwitting Double Agent to Promote Shigella Infection

Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invas...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2018-06, Vol.48 (6), p.1070-1072
Main Authors: Murphy, Alison G., Maloy, Kevin J.
Format: Article
Language:English
Subjects:
alpha-Defensins
Bacteria
Bacterial Adhesion
Dysentery, Bacillary
E coli
Humans
Immunity
Infections
Neutrophils
Pathogenesis
Pathogens
Salmonella
Shigella
Small intestine
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Summary:Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion. Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2018.05.015