Characteristics and outcome of patients with dual hepatitis B and C-associated hepatocellular carcinoma: are they different from patients with single virus infection?

• Published in: Liver international 2009-05, Vol.29 (5), p.767-773
• Main Authors: Huo, Teh-Ia, Huang, Yi-Hsiang, Hsia, Cheng-Yuan, Su, Chien-Wei, Lin, Han-Chieh, Hsu, Chia-Yang, Lee, Pui-Ching, Lui, Wing-Yiu, Loong, Che-Chuan, Chiang, Jen-Huei, Chiou, Yi-You, Lee, Shou-Dong
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - physiopathology; Female; Hepatitis B - complications; Hepatitis B virus; Hepatitis C - complications; Hepatitis C virus; hepatocellular carcinoma; Humans; liver cirrhosis; Liver Neoplasms - etiology; Liver Neoplasms - mortality; Liver Neoplasms - physiopathology; Male; Middle Aged; Neoplasm Staging; Prospective Studies; Risk Assessment; Survival Analysis; Taiwan
• ISSN: 1478-3223; 1478-3231; 1399-1698
• DOI: 10.1111/j.1478-3231.2008.01908.x

s Background: Patients with hepatocellular carcinoma (HCC) caused by dual hepatitis B and C virus (HBV, HCV) infection may constitute a distinct disease group that is different from patients with single virus infection. This study compared the clinical characteristics and outcomes of patients with HBV, HCV and dual virus infection. Methods: A prospective database of 1215 HCC patients with chronic hepatitis B, C or dual virus infection was investigated. Results: Patients with HCV infection (n=388) were significantly older (mean age, 69 years) than patients with dual virus (n=75, 65 years) and HBV (n=752; 60 years) infection (P