Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

Direct physicochemical interactions between the major components of electronic cigarette liquids (e-liquids): glycerol (VG) and propylene glycol (PG), and lung surfactant (LS) were studied by determining the dynamic surface tension under a simulated breathing cycle using drop shape method. The studi...

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Bibliographic Details
Published in:Inhalation toxicology 2018-04, Vol.30 (4-5), p.159-168
Main Authors: Sosnowski, Tomasz R., Jabłczyńska, Katarzyna, Odziomek, Marcin, Schlage, Walter K., Kuczaj, Arkadiusz K.
Format: Article
Language:English
Subjects:
Aerosols
Biological Products - chemistry
Computer Simulation
dynamic surface tension
e-cigarette
Elasticity
Electronic Nicotine Delivery Systems
Glycerol - administration & dosage
Glycerol - adverse effects
Glycerol - chemistry
Inhalation Exposure
Lung surfactant
Models, Chemical
Numerical Analysis, Computer-Assisted
Propylene Glycol - administration & dosage
Propylene Glycol - adverse effects
Propylene Glycol - chemistry
Risk Assessment
surface rheology
Surface Tension
Vaping - adverse effects
Viscosity
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Summary:Direct physicochemical interactions between the major components of electronic cigarette liquids (e-liquids): glycerol (VG) and propylene glycol (PG), and lung surfactant (LS) were studied by determining the dynamic surface tension under a simulated breathing cycle using drop shape method. The studies were performed for a wide range of concentrations based on estimated doses of e-liquid aerosols (up to 2500 × the expected nominal concentrations) and for various VG/PG ratios. The results are discussed as relationships among mean surface tension, surface tension amplitude, and surface rheological properties (dilatational elasticity and viscosity) versus concentration and composition of e-liquid. The results showed that high local concentrations (>200 × higher than the estimated average dose after a single puffing session) may induce measurable changes in biophysical activity of LS; however, only ultra-high e-liquid concentrations inactivated the surfactant. Physiochemical characterization of e-liquids provide additional insights for the safety assessment of electronic nicotine delivery systems (ENDS).
ISSN:0895-8378
1091-7691
DOI:10.1080/08958378.2018.1478916