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The efficacy of silver diamine fluoride in arresting caries in children

Data sourcesPubMed, Scopus, Web of Science, the Latin American and Caribbean Health Sciences Literature database (LILACS), the Brazilian Library in Dentistry (BBO), Cochrane Library and grey literature.Study selectionTwo reviewers selected randomised clinical trials (RCTs) that compared the efficacy...

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Published in:Evidence-based dentistry 2018-06, Vol.19 (2), p.42-43
Main Authors: Seifo, Nassar, Al-Yaseen, Waraf, Innes, Nicola
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creator Seifo, Nassar
Al-Yaseen, Waraf
Innes, Nicola
description Data sourcesPubMed, Scopus, Web of Science, the Latin American and Caribbean Health Sciences Literature database (LILACS), the Brazilian Library in Dentistry (BBO), Cochrane Library and grey literature.Study selectionTwo reviewers selected randomised clinical trials (RCTs) that compared the efficacy of SDF application with other active treatments or placebo in arresting carious lesions.Data extraction and synthesisThree authors extracted data using customised extraction forms, and risk of bias was assessed by two independent reviewers. Meta-analyses were performed on studies classified at 'low' or 'unclear' risk of bias, where similar outcomes were recorded in primary teeth, and that compared SDF to active treatments.ResultsEleven studies were included; five studies were at 'low', two at 'unclear' and four studies at 'high' risk of bias. Eight were conducted with primary teeth, two with permanent first molars and one conducted on both. Six studies used 38% SDF, two 30% SDF, one 12% SDF, one compared 38% SDF to 12% SDF and one used Nano Silver Fluoride (NSF).ConclusionsSDF is more effective than active treatments or placebo for carious lesion arrest in primary teeth. The body of evidence was of high quality for primary teeth. However, there was not enough high quality evidence to draw conclusions about carious lesion arrest in first permanent molars.
doi_str_mv 10.1038/sj.ebd.6401301
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Meta-analyses were performed on studies classified at 'low' or 'unclear' risk of bias, where similar outcomes were recorded in primary teeth, and that compared SDF to active treatments.ResultsEleven studies were included; five studies were at 'low', two at 'unclear' and four studies at 'high' risk of bias. Eight were conducted with primary teeth, two with permanent first molars and one conducted on both. Six studies used 38% SDF, two 30% SDF, one 12% SDF, one compared 38% SDF to 12% SDF and one used Nano Silver Fluoride (NSF).ConclusionsSDF is more effective than active treatments or placebo for carious lesion arrest in primary teeth. The body of evidence was of high quality for primary teeth. However, there was not enough high quality evidence to draw conclusions about carious lesion arrest in first permanent molars.</description><identifier>ISSN: 1462-0049</identifier><identifier>EISSN: 1476-5446</identifier><identifier>DOI: 10.1038/sj.ebd.6401301</identifier><identifier>PMID: 29930376</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Bias ; Children ; Clinical trials ; Data processing ; Dental caries ; Dentistry ; Fluoride treatments ; Fluorides ; Molars ; Teeth</subject><ispartof>Evidence-based dentistry, 2018-06, Vol.19 (2), p.42-43</ispartof><rights>Copyright Nature Publishing Group Jun 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2391-1eb050e883d9d580117338047717068ff843c92ff107b170fe7305448b5cf84d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29930376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seifo, Nassar</creatorcontrib><creatorcontrib>Al-Yaseen, Waraf</creatorcontrib><creatorcontrib>Innes, Nicola</creatorcontrib><title>The efficacy of silver diamine fluoride in arresting caries in children</title><title>Evidence-based dentistry</title><addtitle>Evid Based Dent</addtitle><description>Data sourcesPubMed, Scopus, Web of Science, the Latin American and Caribbean Health Sciences Literature database (LILACS), the Brazilian Library in Dentistry (BBO), Cochrane Library and grey literature.Study selectionTwo reviewers selected randomised clinical trials (RCTs) that compared the efficacy of SDF application with other active treatments or placebo in arresting carious lesions.Data extraction and synthesisThree authors extracted data using customised extraction forms, and risk of bias was assessed by two independent reviewers. Meta-analyses were performed on studies classified at 'low' or 'unclear' risk of bias, where similar outcomes were recorded in primary teeth, and that compared SDF to active treatments.ResultsEleven studies were included; five studies were at 'low', two at 'unclear' and four studies at 'high' risk of bias. Eight were conducted with primary teeth, two with permanent first molars and one conducted on both. Six studies used 38% SDF, two 30% SDF, one 12% SDF, one compared 38% SDF to 12% SDF and one used Nano Silver Fluoride (NSF).ConclusionsSDF is more effective than active treatments or placebo for carious lesion arrest in primary teeth. The body of evidence was of high quality for primary teeth. However, there was not enough high quality evidence to draw conclusions about carious lesion arrest in first permanent molars.</description><subject>Bias</subject><subject>Children</subject><subject>Clinical trials</subject><subject>Data processing</subject><subject>Dental caries</subject><subject>Dentistry</subject><subject>Fluoride treatments</subject><subject>Fluorides</subject><subject>Molars</subject><subject>Teeth</subject><issn>1462-0049</issn><issn>1476-5446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkM1LAzEQxYMotlavHiXgxcvWySbZZI9SahUKXup52U0mNmU_auIK_e9NsV48zfDmx-O9IeSWwZwB149xN8fGzgsBjAM7I1MmVJFJIYrz417kGYAoJ-Qqxh0AKAXykkzysuTAVTElq80WKTrnTW0OdHA0-vYbA7W-7nyP1LXjELxF6ntah4Dxy_cf1NTBYzxqZutbG7C_JheubiPenOaMvD8vN4uXbP22el08rTOT85JlDBuQgFpzW1qpgTHFuQahFFNQaOe04KbMnWOgmiQ5VBxSG91Ik26Wz8jDr-8-DJ9jilN1Phps27rHYYxVDlJL4KXME3r_D90NY-hTuiOltBASRKLuTtTYdGirffBdHQ7V34v4DwlJZcA</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Seifo, Nassar</creator><creator>Al-Yaseen, Waraf</creator><creator>Innes, Nicola</creator><general>Nature Publishing Group</general><scope>NPM</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>The efficacy of silver diamine fluoride in arresting caries in children</title><author>Seifo, Nassar ; Al-Yaseen, Waraf ; Innes, Nicola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2391-1eb050e883d9d580117338047717068ff843c92ff107b170fe7305448b5cf84d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bias</topic><topic>Children</topic><topic>Clinical trials</topic><topic>Data processing</topic><topic>Dental caries</topic><topic>Dentistry</topic><topic>Fluoride treatments</topic><topic>Fluorides</topic><topic>Molars</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seifo, Nassar</creatorcontrib><creatorcontrib>Al-Yaseen, Waraf</creatorcontrib><creatorcontrib>Innes, Nicola</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; 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Meta-analyses were performed on studies classified at 'low' or 'unclear' risk of bias, where similar outcomes were recorded in primary teeth, and that compared SDF to active treatments.ResultsEleven studies were included; five studies were at 'low', two at 'unclear' and four studies at 'high' risk of bias. Eight were conducted with primary teeth, two with permanent first molars and one conducted on both. Six studies used 38% SDF, two 30% SDF, one 12% SDF, one compared 38% SDF to 12% SDF and one used Nano Silver Fluoride (NSF).ConclusionsSDF is more effective than active treatments or placebo for carious lesion arrest in primary teeth. The body of evidence was of high quality for primary teeth. 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subjects Bias
Children
Clinical trials
Data processing
Dental caries
Dentistry
Fluoride treatments
Fluorides
Molars
Teeth
title The efficacy of silver diamine fluoride in arresting caries in children
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