A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis

Objective A lack of published pharmacokinetic data on statins in sepsis has prompted concerns about their safety and toxicity. This study determined single dose pharmacokinetics of Atorvastatin administered orally to acutely ill patients. Design, setting and participants A prospective open label stu...

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Bibliographic Details
Published in:Intensive care medicine 2009-04, Vol.35 (4), p.717-721
Main Authors: Kruger, Peter S., Freir, Noelle M., Venkatesh, Bala, Robertson, Thomas A., Roberts, Michael S., Jones, Mark
Format: Article
Language:English
Subjects:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Anticholesteremic Agents - blood
Anticholesteremic Agents - pharmacokinetics
APACHE
Atorvastatin Calcium
Biological and medical sciences
Brief Report
Chromatography, High Pressure Liquid
Critical Care
Critical Care Medicine
Emergency and intensive care: infection, septic shock
Emergency Medicine
Female
Heptanoic Acids - blood
Heptanoic Acids - pharmacokinetics
Humans
Intensive
Intensive care
Intensive care medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolism
Pain Medicine
Patients
Pediatrics
Pharmacokinetics
Plasma
Pneumology/Respiratory System
Prospective Studies
Pyrroles - blood
Pyrroles - pharmacokinetics
Sepsis
Sepsis - blood
Statins
Toxicity
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Summary:Objective A lack of published pharmacokinetic data on statins in sepsis has prompted concerns about their safety and toxicity. This study determined single dose pharmacokinetics of Atorvastatin administered orally to acutely ill patients. Design, setting and participants A prospective open label study conducted in a tertiary referral centre on 5 healthy volunteers, 5 acutely ill patients admitted to the medical ward and a heterogeneous cohort of 25 critically ill patients admitted to an intensive care unit. Intervention All participants received a single oral dose of 20 mg of atorvastatin. Measurement and results Plasma pharmacokinetics of atorvastatin as measured by maximal plasma concentration (Cmax) and area under the curve (AUC) 0–24 h . Critically ill patients with sepsis had a significantly higher Cmax and AUC as compared to healthy volunteers [110.5(86.5) vs. 5.9(2.50) ng/ml, p  
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-008-1358-3