Mechanisms Mediating Anti-CD3 Antibody Efficacy

:  Anti‐CD3 antibody therapy, a promising clinical approach for the treatment of type 1 diabetes (T1D), was investigated using a mathematical model of T1D in the female nonobese diabetic (NOD) mouse. Analyses of model simulation results indicate that, in addition to the known direct effects of anti‐...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2006-10, Vol.1079 (1), p.369-373
Main Authors: YOUNG, DANIEL L., RAMANUJAN, SAROJA, KREUWEL, HUUB T.C., WHITING, CHAN CHUNG, GADKAR, KAPIL G., SHODA, LISL K.M.
Format: Article
Language:English
Subjects:
145-2C11
antigen presenting cells
diabetes remission
glucose control
systems biology
β cells
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Summary::  Anti‐CD3 antibody therapy, a promising clinical approach for the treatment of type 1 diabetes (T1D), was investigated using a mathematical model of T1D in the female nonobese diabetic (NOD) mouse. Analyses of model simulation results indicate that, in addition to the known direct effects of anti‐CD3 antibody on T lymphocytes, two additional mechanisms are required for sustained disease remission: (a) rapid regrowth of healthy β cells following clearance of islet inflammation and (b) enhanced regulatory T cell activity and/or phenotypic changes in antigen presenting cells (APCs) that promote a stable regulatory environment in the pancreas.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1375.057