Thirty Years of (TMS)3SiH: A Milestone in Radical-Based Synthetic Chemistry

This review is an update on tris­(trimethylsilyl)­silane, TTMSS, in organic chemistry, focusing on the advancements of the past decade. The overview includes a wide range of chemical processes and synthetic strategies under different experimental conditions, including functional group insertion and...

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Bibliographic Details
Published in:Chemical reviews 2018-07, Vol.118 (14), p.6516-6572
Main Authors: Chatgilialoglu, Chryssostomos, Ferreri, Carla, Landais, Yannick, Timokhin, Vitaliy I
Format: Article
Language:English
Online Access:Get full text
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Summary:This review is an update on tris­(trimethylsilyl)­silane, TTMSS, in organic chemistry, focusing on the advancements of the past decade. The overview includes a wide range of chemical processes and synthetic strategies under different experimental conditions, including functional group insertion and transformations, as well as preparation of complex molecules, natural products, polymers, surfaces, and new materials. These results reveal how TTMSS has matured over the past 30 years, and they further establish its value as a free radical reagent with widespread academic and industrial applications.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.8b00109