Association of the ELMO1 gene (snp rs1345365) with development of type 2 diabetes mellitus in the Mexican mestizo population

The g.37190613 locus on 7p14.2-14.1 in the ELMO1 gene has a G>A polymorphism (SNP rs1345365) that has been associated with diabetic nephropathy in different populations. The genetic-association studies in type 2 diabetes mellitus (DM2) on the Mexican population are limited. The aim of this study...

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Bibliographic Details
Published in:Investigación clínica 2015-12, Vol.56 (4), p.341-355
Main Authors: Alberto Ramirez-Garcia, Sergio, Charles-Niño, Claudia, Mazariegos-Rubí, Manuel, Rosalba Topete-González, Luz, Topete-González, Rosalba, Javier Flores-Alvarado, Luis, Leyva Santiago, Jaime, Mosso-González, Clemente, Omayra Dávalos-Rodríguez, Nory
Format: Article
Language:Spanish
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adult
Continental Population Groups
Diabetes Mellitus, Type 2 - genetics
Genetic Predisposition to Disease
Humans
Male
Mexico
Middle Aged
Polymorphism, Single Nucleotide
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Summary:The g.37190613 locus on 7p14.2-14.1 in the ELMO1 gene has a G>A polymorphism (SNP rs1345365) that has been associated with diabetic nephropathy in different populations. The genetic-association studies in type 2 diabetes mellitus (DM2) on the Mexican population are limited. The aim of this study was to estimate whether the polymorphism G>A of ELMO1 gene is associated with the development of DM2. We included 148 DM2 individuals, 156 individuals with cardiovascular risk factors without diabetes and 269 healthy proband without DM2. The polymorphism was identified by PCR amplification specific allele (PASA), PAGE and silver staining. The association was established by genetic epidemiological models; the dominant model showed a positive association (p=0.0006) as a protective factor, and the para-dominant model to heterozygous, as risk factor. In conclusion, this study revealed the association of the SNP rs1345365 of the ELMO1 gene in a Mexican population.
ISSN:0535-5133