Estrogen-related receptor γ regulates expression of 17β-hydroxysteroid dehydrogenase type 1 in fetal growth restriction

Estrogen-related receptor γ (ERRγ) and 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) have important roles in cell invasion and in the proliferation of many types of cancer cells. However, it remains unknown whether ERRγ and HSD17B1 contribute to abnormal placental structure and dysfunction which...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2018-07, Vol.67, p.38-44
Main Authors: Zhu, Hui, Huang, Linhuan, He, Zhiming, Zou, Zhiyong, Luo, Yanmin
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Cells, Cultured
ERRγ
Estradiol Dehydrogenases - genetics
Estradiol Dehydrogenases - metabolism
Female
Fetal growth restriction
Fetal Growth Retardation - genetics
Fetal Growth Retardation - metabolism
Gene Expression Regulation, Enzymologic
HSD17B1
Humans
Infant, Newborn
Male
Placenta - enzymology
Placenta - metabolism
Pregnancy
Receptors, Estrogen - genetics
Receptors, Estrogen - physiology
Trophoblasts
Trophoblasts - enzymology
Trophoblasts - metabolism
Young Adult
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Summary:Estrogen-related receptor γ (ERRγ) and 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) have important roles in cell invasion and in the proliferation of many types of cancer cells. However, it remains unknown whether ERRγ and HSD17B1 contribute to abnormal placental structure and dysfunction which characterize fetal growth restriction (FGR). Therefore, the aim of this study was to investigate the expression profiles of ERRγ and HSD17B1 in placenta tissues affected by FGR and to examine a possible molecular mechanism by which ERRγ is able to regulate HSD17B1 during development of FGR. Placenta tissues were collected from women affected by FGR (n = 28) and from women with appropriately gestational age (AGA) (n = 30). Relative mRNA and protein levels of ERRγ and HSD17B1 in both groups were assessed by quantitative real-time PCR, immunohistochemistry, and Western blot analyses. The effect of ERRγ on trophoblast function and its associated mechanistic details were studied in the trophoblast cell line, HTR-8/SVneo, which was transfected with small interfering RNA (siRNA) targeting ERRγ. Both mRNA and protein levels of ERRγ and HSD17B1 were significantly lower in FGR placentae (P 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2018.05.012