Intravenous fish oil containing lipid emulsion attenuates inflammatory cytokines and the development of bronchopulmonary dysplasia in very premature infants: A double-blind, randomized controlled trial

Preterm infants have lower levels of long-chain polyunsaturated fatty acids (LCPUFAs). Supplementing very premature infants with intravenous lipid emulsions that fish oil, which is rich in n-3 LC-PUFAs, may decrease bronchopulmonary dysplasia (BPD) by modulating inflammation and neonatal immune func...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2019-06, Vol.38 (3), p.1045-1052
Main Authors: Hsiao, Chien-Chou, Lin, Hung-Chih, Chang, Yu-Jun, Yang, Shih-Pan, Tsao, Lon-Yen, Lee, Cheng-Han, Chen, Hsiao-Neng, Chen, Jia-Yuh, Tsai, Yi-Giien
Format: Article
Language:English
Subjects:
Administration, Intravenous
Bronchoalveolar Lavage Fluid - chemistry
Bronchopulmonary dysplasia
Bronchopulmonary Dysplasia - epidemiology
Bronchopulmonary Dysplasia - prevention & control
Bronchopulmonary Dysplasia - therapy
Comorbidity
Cytokines - analysis
DHA
Double-Blind Method
Fat Emulsions, Intravenous - administration & dosage
Fat Emulsions, Intravenous - therapeutic use
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - therapeutic use
Female
Fish oil
Fish Oils - administration & dosage
Fish Oils - therapeutic use
Humans
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Male
n-3 long-chain PUFA
Premature infants
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Summary:Preterm infants have lower levels of long-chain polyunsaturated fatty acids (LCPUFAs). Supplementing very premature infants with intravenous lipid emulsions that fish oil, which is rich in n-3 LC-PUFAs, may decrease bronchopulmonary dysplasia (BPD) by modulating inflammation and neonatal immune function. Sixty very low birth weight (VLBW) premature infants requiring ventilator support were randomized in a double-blind manner to 2 groups and received total parenteral nutrition with fish oil containing LE (intervention group, n = 30) or soybean oil containing LE (control group, n = 30) for 7 days. Blood samples and bronchoalveolar lavage fluid (BALF) were obtained for assay on day 1 and 7 days after LE. The primary outcome was to compare the levels of interleukin (IL)-1β and IL-6 in serum and BALF. Secondary outcomes were to compare mortality and co-morbidities. The levels of IL-1β and IL-6 in serum and BALF were significantly lower in the intervention group at day 8 (p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2018.06.929