Characterization of Topical Antiinflammatory Compounds in Rosmarinus officinatis L

The topical antiinflammatory activity of three extracts at increasing polarity (n-exane, chloroform, and methanol) from the leaves of Rosmarinus officinalis L. (Labiatae) has been tested using the croton oil ear test in mice. Both the n-hexane and the chloroform (CE-1) extracts from the leaves showe...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2007-03, Vol.55 (5), p.1718-1723
Main Authors: Altinier, G, Sosa, S, Aquino, R P, Mencherini, T, Loggia, R D, Tubaro, A
Format: Article
Language:English
Subjects:
Croton
Rosmarinus officinalis
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Summary:The topical antiinflammatory activity of three extracts at increasing polarity (n-exane, chloroform, and methanol) from the leaves of Rosmarinus officinalis L. (Labiatae) has been tested using the croton oil ear test in mice. Both the n-hexane and the chloroform (CE-1) extracts from the leaves showed a dose-dependent activity, the last one possessing an antiinflammatory potency similar to that of indomethacin, the nonsteroidal antiinflammatory drug used as a reference drug (lD sub(50)= 83 and 93 super( mu )g/cm super(2), respectively). The bioassay-oriented fractionation of CE-1 led to the identification of tritepenes, ursolic acid, oleanolic acid, and micromeric acid as the main antiinflammatory principles. Furthermore, the CE-1 extract obtained from the residue of the steam distillation of the leaves (extract A) showed the same antiinflammatory potency of CE-1, suggesting this waste product as a source of antiinflammatory products.
ISSN:0021-8561
DOI:10.1021/jf062610+