Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration

. Aim: To evaluate the effect of inhibiting inducible nitric oxide synthase (iNOS), by aminoguanidine, or leukocyte infiltration, by fucoidin, on gastropathy induced by two different doses of indomethacin in rats. Methods: Rats were treated with saline, aminoguanidine (50 or 100 mg.kg -1 , i. p.) or...

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Published in:Inflammation research 2008, Vol.57 (1), p.28-33
Main Authors: Souza, M. H. L. P., Mota, J. M. S. C., Oliveira, R. B., Cunha, F. Q.
Format: Article
Language:English
Subjects:
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Dermatology
Dose-Response Relationship, Drug
Gastric Mucosa - drug effects
Immunology
Indomethacin - toxicity
Male
Neurology
Neutrophil Infiltration
Nitric Oxide - biosynthesis
Nitric Oxide Synthase Type II - antagonists & inhibitors
Nitric Oxide Synthase Type II - physiology
Peroxidase - metabolism
Pharmacology/Toxicology
Rats
Rats, Wistar
Rheumatology
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Mota, J. M. S. C.
Oliveira, R. B.
Cunha, F. Q.
description . Aim: To evaluate the effect of inhibiting inducible nitric oxide synthase (iNOS), by aminoguanidine, or leukocyte infiltration, by fucoidin, on gastropathy induced by two different doses of indomethacin in rats. Methods: Rats were treated with saline, aminoguanidine (50 or 100 mg.kg -1 , i. p.) or fucoidin (25 mg.kg -1 , i. v.). Indomethacin was then given at a dose of 5 or 20 mg.kg -1 . At the end of 3 h, macroscopic gastric damage and myeloperoxidase (MPO) activity were assessed. Results: Aminoguanidine reduced the gastric damage induced by indomethacin at 20 mg.kg -1 , but increased gastric MPO activity. However, aminoguanidine did not influence the gastric damage induced by indomethacin at 5 mg.kg -1 . Fucoidin prevented both the gastric damage and the increase in gastric MPO activity induced by indomethacin at 20 mg. kg -1 , but not at 5 mg.kg -1 . Conclusion: Indomethacin at a dose of 20 mg.kg -1 , but not at 5 mg.kg -1 , induced gastropathy dependent on neutrophil infiltration and iNOS-generated NO.
doi_str_mv 10.1007/s00011-007-7089-z
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H. L. P. ; Mota, J. M. S. C. ; Oliveira, R. B. ; Cunha, F. Q.</creator><creatorcontrib>Souza, M. H. L. P. ; Mota, J. M. S. C. ; Oliveira, R. B. ; Cunha, F. Q.</creatorcontrib><description>. Aim: To evaluate the effect of inhibiting inducible nitric oxide synthase (iNOS), by aminoguanidine, or leukocyte infiltration, by fucoidin, on gastropathy induced by two different doses of indomethacin in rats. Methods: Rats were treated with saline, aminoguanidine (50 or 100 mg.kg -1 , i. p.) or fucoidin (25 mg.kg -1 , i. v.). Indomethacin was then given at a dose of 5 or 20 mg.kg -1 . At the end of 3 h, macroscopic gastric damage and myeloperoxidase (MPO) activity were assessed. Results: Aminoguanidine reduced the gastric damage induced by indomethacin at 20 mg.kg -1 , but increased gastric MPO activity. However, aminoguanidine did not influence the gastric damage induced by indomethacin at 5 mg.kg -1 . Fucoidin prevented both the gastric damage and the increase in gastric MPO activity induced by indomethacin at 20 mg. kg -1 , but not at 5 mg.kg -1 . Conclusion: Indomethacin at a dose of 20 mg.kg -1 , but not at 5 mg.kg -1 , induced gastropathy dependent on neutrophil infiltration and iNOS-generated NO.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-007-7089-z</identifier><identifier>PMID: 18209962</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Allergology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Dermatology ; Dose-Response Relationship, Drug ; Gastric Mucosa - drug effects ; Immunology ; Indomethacin - toxicity ; Male ; Neurology ; Neutrophil Infiltration ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase Type II - antagonists &amp; inhibitors ; Nitric Oxide Synthase Type II - physiology ; Peroxidase - metabolism ; Pharmacology/Toxicology ; Rats ; Rats, Wistar ; Rheumatology</subject><ispartof>Inflammation research, 2008, Vol.57 (1), p.28-33</ispartof><rights>Birkhaueser 2008</rights><rights>2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-2b311b5f195e8d0e832bd2c3d824a80c0f883441fee2a0eae1005fc9df58e85e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18209962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza, M. 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Results: Aminoguanidine reduced the gastric damage induced by indomethacin at 20 mg.kg -1 , but increased gastric MPO activity. However, aminoguanidine did not influence the gastric damage induced by indomethacin at 5 mg.kg -1 . Fucoidin prevented both the gastric damage and the increase in gastric MPO activity induced by indomethacin at 20 mg. kg -1 , but not at 5 mg.kg -1 . 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H. L. P.</au><au>Mota, J. M. S. C.</au><au>Oliveira, R. B.</au><au>Cunha, F. Q.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. res</stitle><addtitle>Inflamm Res</addtitle><date>2008</date><risdate>2008</risdate><volume>57</volume><issue>1</issue><spage>28</spage><epage>33</epage><pages>28-33</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>. Aim: To evaluate the effect of inhibiting inducible nitric oxide synthase (iNOS), by aminoguanidine, or leukocyte infiltration, by fucoidin, on gastropathy induced by two different doses of indomethacin in rats. Methods: Rats were treated with saline, aminoguanidine (50 or 100 mg.kg -1 , i. p.) or fucoidin (25 mg.kg -1 , i. v.). Indomethacin was then given at a dose of 5 or 20 mg.kg -1 . At the end of 3 h, macroscopic gastric damage and myeloperoxidase (MPO) activity were assessed. Results: Aminoguanidine reduced the gastric damage induced by indomethacin at 20 mg.kg -1 , but increased gastric MPO activity. However, aminoguanidine did not influence the gastric damage induced by indomethacin at 5 mg.kg -1 . Fucoidin prevented both the gastric damage and the increase in gastric MPO activity induced by indomethacin at 20 mg. kg -1 , but not at 5 mg.kg -1 . Conclusion: Indomethacin at a dose of 20 mg.kg -1 , but not at 5 mg.kg -1 , induced gastropathy dependent on neutrophil infiltration and iNOS-generated NO.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>18209962</pmid><doi>10.1007/s00011-007-7089-z</doi><tpages>6</tpages></addata></record>
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source Springer Nature
subjects Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Dermatology
Dose-Response Relationship, Drug
Gastric Mucosa - drug effects
Immunology
Indomethacin - toxicity
Male
Neurology
Neutrophil Infiltration
Nitric Oxide - biosynthesis
Nitric Oxide Synthase Type II - antagonists & inhibitors
Nitric Oxide Synthase Type II - physiology
Peroxidase - metabolism
Pharmacology/Toxicology
Rats
Rats, Wistar
Rheumatology
title Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration
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