High Irisin levels in nondiabetic HIV‐infected males are associated with insulin resistance, nonalcoholic fatty liver disease, and subclinical atherosclerosis

Summary Objective HIV infection is associated with an increased risk of cardiovascular disease. Irisin is a miokyne secreted by skeletal muscle, which may influence insulin homeostasis, nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Our objective was to evaluate the relationships betw...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2018-10, Vol.89 (4), p.414-423
Main Authors: Moreno‐Perez, Oscar, Reyes‐Garcia, Rebeca, Muñoz‐Torres, Manuel, Merino, Esperanza, Boix, Vicente, Reus, Sergio, Giner, Livia, Alfayate, Rocío, Garcia‐Fontana, Beatriz, Sanchez‐Paya, Jose, Picó, Antonio, Portilla, Joaquín
Format: Article
Language:English
Subjects:
Antiretroviral therapy
Arteriosclerosis
Atherosclerosis
cardiovascular
Cardiovascular diseases
carotid intima‐media thickness
CD4 antigen
Diabetes
Diabetes mellitus
Disease resistance
Fatty liver
Hepatitis C
Hip
HIV
Homeostasis
Human immunodeficiency virus
Insulin
insulin homeostasis
Insulin resistance
irisin
Lipodystrophy
Liver diseases
Magnetic resonance spectroscopy
Males
Multivariate analysis
nonalcoholic fatty liver disease
Ribonucleic acid
RNA
Skeletal muscle
Steatosis
subclinical atherosclerosis
Ultrasonography
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Summary:Summary Objective HIV infection is associated with an increased risk of cardiovascular disease. Irisin is a miokyne secreted by skeletal muscle, which may influence insulin homeostasis, nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Our objective was to evaluate the relationships between serum irisin, insulin homeostasis, NAFLD and subclinical atherosclerosis in HIV‐infected males. Design Cross‐sectional study in a cohort of HIV‐infected patients. Patients Inclusion criteria: men older than 18 years; antiretroviral therapy (ART) ‐naïve or on effective ART (
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.13800