Second-order asymmetric transformation and its application for the practical synthesis of α-amino acids

We report a discovery of a new rimantadine [1-(1-adamantyl)ethanamine]-derived chiral ligand and its application for the preparation of α-amino acids using the second-order asymmetric transformation approach. The operational ease of experimental procedures coupled with excellent chemical yields and...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018, Vol.16 (27), p.4968-4972
Main Authors: Takeda, Ryosuke, Kawamura, Akie, Kawashima, Aki, Sato, Tatsunori, Moriwaki, Hiroki, Izawa, Kunisuke, Abe, Hidenori, Soloshonok, Vadim A
Format: Article
Language:English
Subjects:
Amino acids
Organic chemistry
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Summary:We report a discovery of a new rimantadine [1-(1-adamantyl)ethanamine]-derived chiral ligand and its application for the preparation of α-amino acids using the second-order asymmetric transformation approach. The operational ease of experimental procedures coupled with excellent chemical yields and stereochemical outcome suggests some potential synthetic generality of this approach.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00963e