A multicentre study of oral paracoccidioidomycosis: Analysis of 320 cases and literature review

• Published in: Oral diseases 2018-11, Vol.24 (8), p.1492-1502
• Main Authors: Arruda, José Alcides Almeida, Schuch, Lauren Frenzel, Abreu, Lucas Guimarães, Silva, Leni Verônica de Oliveira, Mosconi, Carla, Monteiro, João Luiz Gomes Carneiro, Batista, Aline Carvalho, Hildebrand, Laura de Campos, Martins, Manoela Domingues, Sobral, Ana Paula Veras, Rivero, Elena Riet Correa, Gomes, Ana Paula Neutzling, Silva, Tarcília Aparecida, Vasconcelos, Ana Carolina Uchoa, Mesquita, Ricardo Alves
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alveoli; Biopsy; Brazil - epidemiology; Child; Data processing; Dentistry; Diagnosis; epidemiology; Female; fungal diseases; Geographical variations; Humans; Incidence; Literature reviews; Male; Maxillofacial; Middle Aged; Mouth Diseases - epidemiology; Mouth Diseases - microbiology; mycosis; paracoccidioides; paracoccidioidomycosis; Paracoccidioidomycosis - complications; Paracoccidioidomycosis - epidemiology; Retrospective Studies; Sex Factors; South American blastomycosis; Young Adult
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/odi.12925

Objectives To investigate the frequency of oral paracoccidioidomycosis from representative geographical regions of Brazil and to compare the data with a literature review. Materials and methods A retrospective study was conducted on 108,304 biopsies obtained from 1953 to 2016 at six Brazilian oral and maxillofacial pathology services. Demographic data and clinical and histopathological diagnosis of oral paracoccidioidomycosis were evaluated. A literature review of oral paracoccidioidomycosis studies published in three electronic databases was carried out. Data were analysed descriptively. Results A total of 320 cases of oral paracoccidioidomycosis were surveyed (0.3% of the oral lesions at the centres studied). The lesions were more frequent among male patients. The gingiva/alveolar ridge was the most affected site. Mean age of affected individuals was 51.3 years (±11.7). The literature review showed a higher incidence of oral paracoccidioidomycosis in the south‐east and south regions of Brazil. Male individuals and individuals between 50 and 59 years were most affected. Conclusions Oral paracoccidioidomycosis is an uncommon lesion observed in oral biopsy samples. The differences in the relative frequency of oral paracoccidioidomycosis are related to geographical variations. Men between 50 and 59 years are more affected. This study provides helpful information for clinicians in the diagnosis of oral paracoccidioidomycosis.