Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: A Children's Oncology Group phase II study

Background The prognosis for children with brain stem glioma remains grim. Based on studies suggesting efficacy of vincristine and oral VP‐16, The Pediatric Oncology Group (POG, now part of the Children's Oncology Group) conducted a study using these agents in combination with standard external...

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Bibliographic Details
Published in:Pediatric Blood & Cancer 2008-02, Vol.50 (2), p.227-230
Main Authors: Korones, David N., Fisher, Paul G., Kretschmar, Cynthia, Zhou, Tianni, Chen, Zhengjia, Kepner, James, Freeman, Carolyn
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
brain stem glioma
Brain Stem Neoplasms - drug therapy
Brain Stem Neoplasms - radiotherapy
Child
children
Combined Modality Therapy
etoposide
Etoposide - administration & dosage
Etoposide - adverse effects
Glioma - drug therapy
Glioma - radiotherapy
Humans
oral VP-16
Radiotherapy - adverse effects
Survival Rate
Treatment Outcome
vincristine
Vincristine - administration & dosage
Vincristine - adverse effects
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Summary:Background The prognosis for children with brain stem glioma remains grim. Based on studies suggesting efficacy of vincristine and oral VP‐16, The Pediatric Oncology Group (POG, now part of the Children's Oncology Group) conducted a study using these agents in combination with standard external beam radiation for children with newly diagnosed brain stem glioma. Methods Children were eligible for the study if they 3–21 years of age, had MRI‐evidence of a diffuse intrinsic pontine glioma, and had neurologic deficits of
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.21154