Gene regulatory networks that control the specification of neural-crest cells in the lamprey

The lamprey is the only basal vertebrate in which large-scale gene perturbation analyses are feasible at present. Studies on this unique animal model promise to contribute both to the understanding of the basic neural-crest gene regulatory network architecture, and evolution of the neural crest. In...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2009-04, Vol.1789 (4), p.274-278
Main Authors: Nikitina, Natalya V., Bronner-Fraser, Marianne
Format: Article
Language:English
Subjects:
Animals
Cell Lineage - genetics
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - metabolism
Gene regulatory network
Gene Regulatory Networks
Lamprey
Lampreys - embryology
Lampreys - genetics
Neural crest
Neural Crest - growth & development
Neural Crest - metabolism
Petromyzontidae
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Summary:The lamprey is the only basal vertebrate in which large-scale gene perturbation analyses are feasible at present. Studies on this unique animal model promise to contribute both to the understanding of the basic neural-crest gene regulatory network architecture, and evolution of the neural crest. In this review, we summarize the currently known regulatory relationships underlying formation of the vertebrate neural crest, and discuss new ways of addressing the many remaining questions using lamprey as an experimental model.
ISSN:1874-9399
0006-3002
1876-4320
DOI:10.1016/j.bbagrm.2008.03.006