Anti-Tobacco Mosaic Virus Quassinoids from Ailanthus altissima (Mill.) Swingle

Quassinoids are bitter constituents characteristic of the family Simaroubaceae. A total of 18 C20 quassinoids, including nine new quassinoid glycosides, named chuglycosides A–I (1–6 and 8–10), were identified from the samara of Ailanthus altissima (Mill.) Swingle. All of the quassinoids showed poten...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2018-07, Vol.66 (28), p.7347-7357
Main Authors: Tan, Qing-Wei, Ni, Jian-Cheng, Zheng, Lu-Ping, Fang, Pei-Hua, Shi, Jian-Ting, Chen, Qi-Jian
Format: Article
Language:English
Subjects:
Ailanthus - chemistry
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Nicotiana - virology
Plant Diseases - virology
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Quassins - chemistry
Quassins - isolation & purification
Quassins - pharmacology
Structure-Activity Relationship
Tobacco Mosaic Virus - drug effects
Tobacco Mosaic Virus - physiology
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Summary:Quassinoids are bitter constituents characteristic of the family Simaroubaceae. A total of 18 C20 quassinoids, including nine new quassinoid glycosides, named chuglycosides A–I (1–6 and 8–10), were identified from the samara of Ailanthus altissima (Mill.) Swingle. All of the quassinoids showed potent anti-tobacco mosaic virus (TMV) activity. A preliminary structure–anti-TMV activity relationship of quassinoids was discussed. The effects of three quassinoids, including chaparrinone (12), glaucarubinone (15), and ailanthone (16), on the accumulation of TMV coat protein (CP) were studied by western blot analysis. Ailanthone (16) was further investigated for its influence on TMV spread in the Nicotiana benthamiana plant.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.8b01280