Serum Arginase II level can be a novel indicator for erectile dysfunction in patients with vasculogenic erectile dysfunction: a comparative study

Purpose The purpose of the study was to compare serum level of Arginase II in patients with vasculogenic erectile dysfunction (ED) versus healthy controls and to assess if its level is affected by severity of ED. Methods This is a prospective study that compared Arginase II in 40 patients with ED ve...

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Bibliographic Details
Published in:International urology and nephrology 2018-08, Vol.50 (8), p.1389-1395
Main Authors: Abdel Wahed, Abdel Shakour Abdel Hafez, Amer, Mohamed Abdel Mawgood, Abou Mohamed, Nagah Mohamed, Mobasher, Mohamed Ismael, Mamdouh, Hassan, GamalEl Din, Sameh Fayek, ElSheemy, Mohammed Said
Format: Article
Language:English
Subjects:
Adult
Arginase
Arginase - blood
Biomarkers - blood
Diabetes mellitus
Drug addiction
Enzyme-Linked Immunosorbent Assay
Erectile dysfunction
Follow-Up Studies
Health risk assessment
Humans
Impotence, Vasculogenic - diagnosis
Impotence, Vasculogenic - enzymology
Impotence, Vasculogenic - physiopathology
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Penile Erection - physiology
Prospective Studies
Severity of Illness Index
Smoking
Spectrophotometry
Surgery
Surveys and Questionnaires
Time Factors
Trauma
Urology
Urology - Original Paper
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Summary:Purpose The purpose of the study was to compare serum level of Arginase II in patients with vasculogenic erectile dysfunction (ED) versus healthy controls and to assess if its level is affected by severity of ED. Methods This is a prospective study that compared Arginase II in 40 patients with ED versus 40 healthy controls. Patients were excluded if they had any pelvic trauma or pelvic surgery, hormonal disorders, Peyronie’s disease, smoking, drug addiction or systemic illnesses. ED was evaluated by the validated Arabic version of the abbreviated five-item form of the international index of erectile function (IIEF-5). Serum arginase II level was assayed using ELIZA. Mann–Whitney, Kruskal–Wallis and Chi-square tests and Spearman correlation were used as appropriate and confirmed by logistic regression model. Results 22 (55%) patients had DM. 15 (37.5%), 7 (17%), 6 (15%) and 12 (30%) patients suffered from severe, moderate, mild to moderate and mild ED, respectively. The level of serum Arginase II was significantly higher in patients than controls ( p  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-018-1921-y