Translocation positive acute myeloid leukemia associated with valproic acid therapy

Valproic acid is an effective anti‐epileptic medication often used for long‐term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia. Here, we report a case of valproic acid‐related leukemia‐like syndrome with...

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Bibliographic Details
Published in:Pediatric Blood & Cancer 2008-03, Vol.50 (3), p.641-643
Main Authors: Williams Jr, David C., Massey, Gita V., Russell, E. Clifton, Riley, Roger S., Ben-Ezra, Jonathan
Format: Article
Language:English
Subjects:
16
Acute Disease
acute myeloid leukemia
Anticonvulsants - administration & dosage
Anticonvulsants - adverse effects
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Cell Differentiation
Cell Division - drug effects
Child, Preschool
Chromosomes, Human, Pair 16 - genetics
Chromosomes, Human, Pair 16 - ultrastructure
Chromosomes, Human, Pair 8 - genetics
Chromosomes, Human, Pair 8 - ultrastructure
Clone Cells - drug effects
Clone Cells - ultrastructure
Cocarcinogenesis
Drug Therapy, Combination
Epilepsy, Absence - drug therapy
Female
histone deacetylase inhibitors
Humans
Isoxazoles - administration & dosage
Isoxazoles - therapeutic use
Leukemia, Myeloid - chemically induced
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - ultrastructure
Oncogene Proteins, Fusion - genetics
Phenobarbital - administration & dosage
Phenobarbital - therapeutic use
Piracetam - administration & dosage
Piracetam - analogs & derivatives
Piracetam - therapeutic use
t(8
16)
Translocation, Genetic
Triazines - administration & dosage
Triazines - therapeutic use
valproic acid
Valproic Acid - administration & dosage
Valproic Acid - adverse effects
Valproic Acid - pharmacology
Valproic Acid - therapeutic use
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Description
Summary:Valproic acid is an effective anti‐epileptic medication often used for long‐term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia. Here, we report a case of valproic acid‐related leukemia‐like syndrome with a t(8;16) chromosomal translocation. After discontinuing valproic acid, the hematological findings completely resolved. Pediatr Blood Cancer 2008;50:641–643. © 2007 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.21149