Morphometric studies of cardiac miocytes of rats chronically treated with an organophosphate

Organophosphate intoxication induces an acute cholinergic syndrome, but the long-term effects of these compounds in the cardiocirculatory system are not known. The objective of the present work is to investigate if experimental chronic exposition to repetitive sublethal doses of organophosphate meth...

Full description

Saved in:
Bibliographic Details
Published in:Ecotoxicology and environmental safety 2007-03, Vol.66 (3), p.447-450
Main Authors: Calore, E.E., Perez, N.M., Herman, M.M.
Format: Article
Language:English
Subjects:
Animal, plant and microbial ecology
Applied ecology
Biological and medical sciences
Cholinesterase inhibitors
Ecotoxicology, biological effects of pollution
Fundamental and applied biological sciences. Psychology
General aspects
Heart
Heart failure
Morphometry
Organophosphate
Pesticide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organophosphate intoxication induces an acute cholinergic syndrome, but the long-term effects of these compounds in the cardiocirculatory system are not known. The objective of the present work is to investigate if experimental chronic exposition to repetitive sublethal doses of organophosphate methamidophos can induce morphological changes in rat's hearts. Wistar albino adult male rats received a weekly enteral sublethal dose of the organophosphate methamidophos for 12 consecutive weeks. After that we have performed histological and morphometric studies of their hearts. We have observed hypertrophy of cardiac myocites in treated animals, which was confirmed by morphometric studies (measure of smaller diameter of cardiac myocites). One of the possible explanations for the cardiac hypertrophy would be persistent systemic arterial hypertension in treated animals. However, another possible explanation would be direct sympathetic stimulation.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2006.04.001