Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds

Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural product...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2018/07/01, Vol.41(7), pp.979-984
Main Authors: Yokoyama, Takeshi, Mizuguchi, Mineyuki
Format: Article
Language:English
Subjects:
Amyloid
amyloid fibril disrupter
Amyloidogenesis
Amyloidosis
crystal structure
Lead compounds
Mutation
natural product
Natural products
stabilizer
Transthyretin
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Summary:Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural products and synthetic compounds that have been shown to inhibit the amyloidogenesis of TTR. The stabilizers and/or the amyloid fibril disrupters isolated from natural sources may become lead compounds for the treatment of TTR-related amyloidosis.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b18-00166