Nanoliter-Scale Electromembrane Extraction and Enrichment in a Microfluidic Chip

This paper reports for the first time nanoliter-scale electromembrane extraction (nanoliter-scale EME) in a microfluidic device. Six basic drug substances (model analytes) were extracted from 70 μL samples of human whole blood, plasma, or urine through a supported liquid membrane (SLM) of 2-nitrophe...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2018-08, Vol.90 (15), p.9322-9329
Main Authors: Hansen, Frederik A, Sticker, Drago, Kutter, Jörg P, Petersen, Nickolaj J, Pedersen-Bjergaard, Stig
Format: Article
Language:English
Subjects:
Analytical chemistry
Biochips
Blood
Chemistry
Drugs
Enrichment
Feasibility studies
Formic acid
Mass production
Materials selection
Microfluidics
Plasma
Polymers
Urinalysis
Urine
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Summary:This paper reports for the first time nanoliter-scale electromembrane extraction (nanoliter-scale EME) in a microfluidic device. Six basic drug substances (model analytes) were extracted from 70 μL samples of human whole blood, plasma, or urine through a supported liquid membrane (SLM) of 2-nitrophenyl octyl ether (NPOE) and into 6 nL of 10 mM formic acid as an acceptor solution. A DC potential of 15 V was applied across the SLM and served as the driving force for the extraction. The cathode was located in the acceptor solution. Because of the small area of the SLM (0.06 mm2), the system provided soft extraction with recoveries
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.8b01936