Antidepressant-Resistant Depression in Patients With Comorbid Subclinical Hypothyroidism or High-Normal TSH Levels

Cohen et al discuss two cases of antidepressant-resistant depression in patients with comorbid subclinical hypothyroidism or high-normal TSH levels. In case 1, a 35-year-old woman with a history of previous depression responsive to imipraminc at 150 mg/day presented with a second depressive episode...

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Bibliographic Details
Published in:American Journal of Psychiatry 2018-07, Vol.175 (7), p.598-604
Main Authors: Cohen, Bruce M, Sommer, Barbara R, Vuckovic, Alexander
Format: Article
Language:English
Subjects:
Antidepressants
Comorbidity
Drug resistance
Hypothyroidism
Mental depression
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Summary:Cohen et al discuss two cases of antidepressant-resistant depression in patients with comorbid subclinical hypothyroidism or high-normal TSH levels. In case 1, a 35-year-old woman with a history of previous depression responsive to imipraminc at 150 mg/day presented with a second depressive episode that met criteria for major depressive disorder. In case 2, a 52-year-old woman had experienced episodes of depression in college and after the birth of her second child. These episodes responded well to fluoxetine and, later, escitalopram at 10 mg/day. Escitalopram was continued as maintenance treatment at 10 mg/day.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2017.17080949