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Human Papillomavirus Infections in Lung Cancer. Detection of E6 and E7 Transcripts and Review of the Literature
Lung cancer is the leading cause of cancer related death in Western countries. Several factors have been implicated in its aetiology: cigarette smoking, environmental pollution, asbestos and genetic factors. The possible involvement of human papillomavirus (HPV) in bronchial squamous cell lesions wa...
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| Published in: | Anticancer research 2007-07, Vol.27 (4C), p.2697-2704 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 2704 |
| container_issue | 4C |
| container_start_page | 2697 |
| container_title | Anticancer research |
| container_volume | 27 |
| creator | GIULIANI, Laura FAVALLI, Cartesio SYRJANEN, Kari CIOTTI, Marco |
| description | Lung cancer is the leading cause of cancer related death in Western countries. Several factors have been implicated in its
aetiology: cigarette smoking, environmental pollution, asbestos and genetic factors. The possible involvement of human papillomavirus
(HPV) in bronchial squamous cell lesions was first suggested in 1979 by Syrjänen. Since then, several studies have confirmed
the presence of HPV DNA in about 20% of lung cancer cases examined, with HPV16 and 18 as the two most frequently found oncogenic
viral types. More recently, these data have been supported by the detection of E6 and E7 transcripts in HPV-positive lung
cancer cases, reinforcing the hypothesis that oncogenic HPVs could act as cofactors in bronchial carcinogenesis. This published
literature is briefly reviewed and new data of the authors on detection of E6 and E7 transcripts in lung cancer samples are
presented. |
| format | article |
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aetiology: cigarette smoking, environmental pollution, asbestos and genetic factors. The possible involvement of human papillomavirus
(HPV) in bronchial squamous cell lesions was first suggested in 1979 by Syrjänen. Since then, several studies have confirmed
the presence of HPV DNA in about 20% of lung cancer cases examined, with HPV16 and 18 as the two most frequently found oncogenic
viral types. More recently, these data have been supported by the detection of E6 and E7 transcripts in HPV-positive lung
cancer cases, reinforcing the hypothesis that oncogenic HPVs could act as cofactors in bronchial carcinogenesis. This published
literature is briefly reviewed and new data of the authors on detection of E6 and E7 transcripts in lung cancer samples are
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aetiology: cigarette smoking, environmental pollution, asbestos and genetic factors. The possible involvement of human papillomavirus
(HPV) in bronchial squamous cell lesions was first suggested in 1979 by Syrjänen. Since then, several studies have confirmed
the presence of HPV DNA in about 20% of lung cancer cases examined, with HPV16 and 18 as the two most frequently found oncogenic
viral types. More recently, these data have been supported by the detection of E6 and E7 transcripts in HPV-positive lung
cancer cases, reinforcing the hypothesis that oncogenic HPVs could act as cofactors in bronchial carcinogenesis. This published
literature is briefly reviewed and new data of the authors on detection of E6 and E7 transcripts in lung cancer samples are
presented.</description><subject>Biological and medical sciences</subject><subject>DNA, Viral - analysis</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 16</subject><subject>Humans</subject><subject>Lung Neoplasms - virology</subject><subject>Medical sciences</subject><subject>Oncogene Proteins, Viral - biosynthesis</subject><subject>Oncogene Proteins, Viral - genetics</subject><subject>Oncogenes</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - virology</subject><subject>Pneumology</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpFkMFOwzAQRC0EglL4BeQL3ILsOPEmR1QKrVQJhOAcbdx1a5Q4xU5A_D0BijitNPt2RjsHbCKhlAnkShyyiUhzkYAQ-Qk7jfFVCK3LQh2zEwm6zDOVT1i3GFr0_BF3rmm6Ft9dGCJfekumd52P3Hm-GvyGz9AbCtf8lvrfFe8sn2uOfs3nwJ8D-miC2_XxR3qid0cf30y_Jb5yPQXsh0Bn7MhiE-l8P6fs5W7-PFskq4f75exmlWyVkH2SSYCaYI0oM2mtgjVpZRVqyssCCgGFyY01qkRpcyvTupZUG0jJgh4vMzVlV7--u9C9DRT7qnXRUNOgp26IVSq0KtTYxpRd7MGhbmld7YJrMXxWfxWNwOUewGiwseOjxsV_rih1Cin8J27dZvvhAlWxxaYZbVWFIYUqm1WpLkF9ASZffbY</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>GIULIANI, Laura</creator><creator>FAVALLI, Cartesio</creator><creator>SYRJANEN, Kari</creator><creator>CIOTTI, Marco</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20070701</creationdate><title>Human Papillomavirus Infections in Lung Cancer. Detection of E6 and E7 Transcripts and Review of the Literature</title><author>GIULIANI, Laura ; FAVALLI, Cartesio ; SYRJANEN, Kari ; CIOTTI, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-4177be7daa141ff37de63f3a6e59878078c5cfc39a1f5f12bb1ebc72ef7677b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>DNA, Viral - analysis</topic><topic>Human papillomavirus</topic><topic>Human papillomavirus 16</topic><topic>Humans</topic><topic>Lung Neoplasms - virology</topic><topic>Medical sciences</topic><topic>Oncogene Proteins, Viral - biosynthesis</topic><topic>Oncogene Proteins, Viral - genetics</topic><topic>Oncogenes</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - virology</topic><topic>Pneumology</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIULIANI, Laura</creatorcontrib><creatorcontrib>FAVALLI, Cartesio</creatorcontrib><creatorcontrib>SYRJANEN, Kari</creatorcontrib><creatorcontrib>CIOTTI, Marco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIULIANI, Laura</au><au>FAVALLI, Cartesio</au><au>SYRJANEN, Kari</au><au>CIOTTI, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Papillomavirus Infections in Lung Cancer. Detection of E6 and E7 Transcripts and Review of the Literature</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>27</volume><issue>4C</issue><spage>2697</spage><epage>2704</epage><pages>2697-2704</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Lung cancer is the leading cause of cancer related death in Western countries. Several factors have been implicated in its
aetiology: cigarette smoking, environmental pollution, asbestos and genetic factors. The possible involvement of human papillomavirus
(HPV) in bronchial squamous cell lesions was first suggested in 1979 by Syrjänen. Since then, several studies have confirmed
the presence of HPV DNA in about 20% of lung cancer cases examined, with HPV16 and 18 as the two most frequently found oncogenic
viral types. More recently, these data have been supported by the detection of E6 and E7 transcripts in HPV-positive lung
cancer cases, reinforcing the hypothesis that oncogenic HPVs could act as cofactors in bronchial carcinogenesis. This published
literature is briefly reviewed and new data of the authors on detection of E6 and E7 transcripts in lung cancer samples are
presented.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17695435</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Anticancer research, 2007-07, Vol.27 (4C), p.2697-2704 |
| issn | 0250-7005 1791-7530 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Biological and medical sciences DNA, Viral - analysis Human papillomavirus Human papillomavirus 16 Humans Lung Neoplasms - virology Medical sciences Oncogene Proteins, Viral - biosynthesis Oncogene Proteins, Viral - genetics Oncogenes Papillomaviridae - genetics Papillomavirus Infections - complications Papillomavirus Infections - virology Pneumology RNA, Messenger - analysis RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumors Tumors of the respiratory system and mediastinum |
| title | Human Papillomavirus Infections in Lung Cancer. Detection of E6 and E7 Transcripts and Review of the Literature |
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