Solubilization of Dipropofol, an Antibacterial Agent, Using Saccharide and Ascorbic Acid

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosac...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2007/08/01, Vol.30(8), pp.1565-1568
Main Authors: Ogata, Masahiro, Oka, Kentaro, Seki, Masako, Hoshi, Midori, Takatsu, Hirokatsu, Mashino, Tadahiko, Urano, Shiro, Endo, Toyoshige
Format: Article
Language:English
Subjects:
Alkanes - chemistry
Alkanes - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
ascorbic acid
Ascorbic Acid - chemistry
dipropofol
Drug Synergism
Escherichia coli - drug effects
Excipients
Microbial Sensitivity Tests
monosaccharide
Monosaccharides - chemistry
Oxidation-Reduction
Phenols - chemistry
Phenols - pharmacology
Solubility
solubilization
Staphylococcus aureus - drug effects
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Summary:Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.30.1565