Extrathymic rearrangement of alpha beta T-lymphocyte antigen receptor genes during pregnancy

The existence of alpha beta T-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrea...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2007-09, Vol.72 (9), p.983-988
Main Authors: Shirshev, S V, Kuklina, E M, Maksimov, AYu, Krapivina, O A, Parshakova, N S
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The existence of alpha beta T-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha -chain (pre-TCR alpha ) preferentially in T-lymphocytes of lymph nodes involved in uterine drainage (para-aortal lymph nodes), and to a lesser extent in other lymph nodes (mainly from axillary lymph nodes). The data suggest that during pregnancy the differentiation of alpha beta T lymphocytes may occur not only in central (thymus) but also in peripheral lymphoid organs.
ISSN:0006-2979
0320-9725
DOI:10.1134/S000629790709009X