Loading…

Angiotensin II induces type I collagen gene expression in human dermal fibroblasts through an AP-1/TGF-b1-dependent pathway

Angiotensin II is critically involved in skin wound healing, but the underlying mechanism remains unclear. This study investigated the effect of angiotensin II on type I collagen gene activation in human dermal fibroblasts and the possible mechanism involved. Angiotensin II stimulated the mRNA and p...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-07, Vol.385 (3), p.418-423
Main Authors: Tang, H T, Cheng, D S, Jia, Y T, Ben, D F, Ma, B, Lv, KY, Wei, D, Sheng, Z Y, Xia, Z F
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Angiotensin II is critically involved in skin wound healing, but the underlying mechanism remains unclear. This study investigated the effect of angiotensin II on type I collagen gene activation in human dermal fibroblasts and the possible mechanism involved. Angiotensin II stimulated the mRNA and protein expression of type I collagen and TGF-b1. Effects were abolished by the angiotensin AT1 receptor antagonist ZD7155 but not by the AT2 blocker PD123319. Blockade of TGF-b1 markedly inhibited angiotensin II-induced type I collagen gene expression. Activator protein-1 (AP-1) decoy ODNs transfection suppressed angiotensin II-induced TGF-b1 expression, and also, diminished type I collagen expression. These data indicated that angiotensin II induces collagen gene activation in human dermal fibroblasts through an AT1-mediated AP-1/TGF-b1 signaling pathway.
ISSN:0006-291X
DOI:10.1016/j.bbrc.2009.05.081