Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription

The contribution of long noncoding RNAs (lncRNAs) to pancreatic cancer progression and the regulatory mechanisms of their expression are attractive areas. In the present study, the overexpression of lncRNA-BX111887 (BX111) in pancreatic cancer tissues was detected by microarray and further validated...

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Bibliographic Details
Published in:Oncogene 2018-11, Vol.37 (44), p.5811-5828
Main Authors: Deng, Shi-jiang, Chen, Heng-yu, Ye, Zeng, Deng, Shi-chang, Zhu, Shuai, Zeng, Zhu, He, Chi, Liu, Ming-liang, Huang, Kang, Zhong, Jian-xin, Xu, Feng-yu, Li, Qiang, Liu, Yang, Wang, Chun-you, Zhao, Gang
Format: Article
Language:English
Subjects:
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Animals
Apoptosis
Care and treatment
Cell Biology
Cell Hypoxia
Cell Line, Tumor
Cell proliferation
Development and progression
Disease Progression
DNA microarrays
E-cadherin
Epithelial-Mesenchymal Transition - genetics
Epithelial-Mesenchymal Transition - physiology
Gelatinase A
Gene expression
Gene Expression Regulation, Neoplastic
Genetic aspects
Health aspects
Human Genetics
Humans
Hypoxia
Hypoxia-Inducible Factor 1 - genetics
Hypoxia-Inducible Factor 1 - metabolism
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Hypoxia-inducible factors
Internal Medicine
Lymphatic Metastasis
Medicine
Medicine & Public Health
Mesenchyme
Metastases
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
Oncology
Pancreatic cancer
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - physiopathology
Pancreatic Neoplasms - secondary
RNA, Long Noncoding - metabolism
RNA, Long Noncoding - physiology
Therapeutic applications
Transcription factors
Transcription, Genetic
Xenografts
Y-Box-Binding Protein 1 - genetics
Y-Box-Binding Protein 1 - metabolism
Zinc Finger E-box-Binding Homeobox 1 - genetics
Zinc Finger E-box-Binding Homeobox 1 - metabolism
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